Blood and organs, in which the formation of blood cells - blood - and their destruction, unite on the proposal, F. lang in a single system of blood. This system include: bone marrow, liver, spleen and lymph glands. Body of blood in adult organism is the bone marrow, and the embryo, in addition, and liver. Adult hematopoietic function of the liver is lost.
In the day, there are approximately 200-250 billion red blood cells. The founders of a nuclear-free erythrocytes are having the core of urethroplasty red bone marrow. In their cytoplasm, more precisely in granules consisting of ribosomes, hemoglobin are synthesized. In the synthesis of heme, apparently, is used iron, part two proteins ferritin and sideration. Entering the blood from the bone marrow erythrocytes contain basophilic substance (painted main colors) and are called reticulocytes. The largest they are more Mature erythrocytes. Their content in the blood of a healthy person does not exceed 1%. The maturation of reticulocytes, i.e. their transformation in the Mature erythrocytes - normocytes takes place within a few hours; this basophilic substance in them disappears.
The number of reticulocytes in the blood is the intensity of formation of red blood cells in the bone marrow.
The life of red blood cells in average equal to 120 days. It can be defined in various ways. In recent years, for this purpose apply a methodology labeled" atoms. In human blood enter the labeled red blood cells containing a radioactive isotope of chromium (Cr51) or iron (Fe59).
The destruction of obsolete erythrocytes takes place continuously by their hemolysis in the cells of the reticulo-endothelial system, primarily in the liver and spleen. These bodies called the graveyard of red blood cells".
For the formation of red blood cells - erythropoiesis - it is necessary that the intake of stimulating the process of vitamins - vitamin B12 and Polevoy acid. The first of these substances is approximately 1000 times more active than the second. Vitamin B12 - ciankobalamin - is an external factor blood entering the body with food from the environment. It absorbed in the digestive tract only if cancer of the stomach secrete mucoprotein called internal factor in the blood. According to some reports, internal factor catalyzes some enzymatic process, directly associated with the absorption of vitamin B12. In the absence of education in the stomach internal factor is disrupted supply of vitamin B12, which entails violation of the formation of red blood cells in the bone marrow.