The effect of drugs on the body

Pages: 1 2 3 4 5 6 7 8 9 10

Biotransformation of drugs in an aging body examines geriatric pharmacology. Increased sensitivity to older drugs associated with a decrease in the relative weight of the liver as aging and morphological changes in the liver cells. Added to this is the age-related decline excretion of electrolytes and water by the kidneys.
It is necessary to consider also the qualitative and quantitative features of the power supply. It can be shown by changing the properties of drugs in the intestine, shifts in the dynamics of absorption of protein binding of the blood, metabolism and excretion. Each of these stages affect the detoxification of chemical compounds, At a lack of supply many factors reduce drug metabolism; but especially true deficiency in the diet of protein, inhibiting the secretion from the body of medicinal substances and increasing the duration of their action.
Complex influence on the metabolism of drugs have a variety of pathological conditions. For example, infections, diabetes, various liver reduce the speed biotransformation and increase the body's sensitivity. Thus, conditions are created for overdose introduced into the body of drugs. The essential mechanism of drug effects on the biotransformation is the impact of drugs on the activity of enzymesthat neutralize them. The interaction of the organism with medication ends eventually arise it either unchanged or (more often) in the form of certain metabolites. The kidneys and bowels - the main route of excretion of drugs. But not the only one. There are other light, the sweat glands.
It is extremely important to know the fate of drugs in the body, as it determines the effectiveness of pharmacotherapy and gives the opportunity to predict adverse reactions.
No doubt that the choice of the dosage form, and route of administration are essential for the success of pharmacotherapy. Dosage form with the whole set of properties (not just the active substance) affects a specific process in the body. The wrong choice, it may cause increased or greatly weakened activity of the drug, which ultimately can lead to its complete ineffectiveness. The speed of delivery of the substances in the blood and its concentration in it are the main indicators that are both characterize the healing properties of a particular medicine.
Long established that the power and influence of drugs largely depends on the "form"in which it enters a living organism. The comparative evaluation of powders, tablets, medicinal muds established an impressive difference in the rate of absorption and time for the presence of drugs in the body. Many of them after the introduction (for example, in rectal suppositories) were found in biological fluids in the earlier period and in sufficient quantity. This concentration was well supported by the necessary "treatment resistance". Here is an example. Levomepromazine assigned in the form of suppositories, acted in the blood of patients after 10-15 minutes, and adopted at the same dose in the form of tablets none of these patients has not been detected within 30 minutes is Allocated a specified drug in urine is also faster in those patients who received the drug in the form of the same suppositories.
Intramuscular injection of solution of crystalline powder ascorbic acid maximum concentration is reached in an hour and maintained at a high level in the next hour. Oral powder is characterized by a slower absorption. Maximum concentration (especially in the blood) in this case is much lower. It is important that after injection of ascorbic acid accumulation of vitamin C in the liver is found in the moment when its content in the blood begins to decline. But with a dose rate of absorption into the blood and accumulation of drugs in the liver changes synchronously.