The effect of drugs on the body

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Experiments and numerous literary data allow to assert, that the right dosage forms of hormonal drugs subject to certain advantages of one or the other of them in each case, undoubtedly, is one of the important principles of hormonal therapy. We can say with confidence that many of the side effects of steroid preparations with any degree of defeat of the gastrointestinal tract and relevant pathological reactions of the organs of digestion, prevents the correct selection of medicinal forms. It must take into account every doctor's office in connection with the widest use of steroids in modern therapy and frequency of diseases of the gastrointestinal tract.
Further study of medicinal forms and ways of their introduction will allow to significantly improve the effectiveness of drugs and to reduce possible adverse their actions.
The problem side effects of drugs in our time has become especially acute, as in the therapeutic Arsenal includes medicines with high biological activity, which range between therapeutic and toxic dose is small. At 5-7 percent of patients treated with various medications, there are adverse reactions, sometimes life-threatening. It is established that the side effects of different severity can develop from taking almost all of drugs available in the Public registry.
In the last decade has conducted a special study of the pathogenesis of side effects of drugs developed thin laboratory techniques, allowing it to diagnose. Many countries have established national centers, and with the world health organization - international center for monitoring the safety of medicines. On the basis of clinical and pathogenetic data to the proposed working classification side effects of drugs.
Prescribing medication usually try to influence some polling function of the body, certain groups of receptors, which are closely linked with functions of various organs. Therefore, providing a therapeutic effect, the drug simultaneously affects the activity of other, healthy bodies, calling on their side adverse reactions. Neiroleptiki, for example, along with psychocorrection effect lead at 40-50 percent of the mentally ill to various extrapyramidal disorders. Tuberculostatic funds isoniazidum row cause euphoria. It was used to create a new class of drugs, antidepressants.
Side pharmacological effect usually occurs from the middle and especially high, but therapeutic doses of the drug. At ultrahigh this effect is coming to another kind of drug pathology - toxicity, which is most obvious in cases of overdose, that is too much medication in the body. In these cases, dramatically increases pharmacological effect. The product can accumulate in the body and insufficient its excretion, not only because of the defects of the urinary system, but also by its pharmacological properties - cumulative properties.
There is also a metabolic toxicity. Metabolites as products of pharmacodynamics of the drug in the body sometimes much more toxic than the original drugs, and then they cause of medicinal complications. For example, an antimalarial drug chloroquine is converted in the body into metabolite Aminogen, which can cause toxic optic neuritis and retinopathy.