The effect of drugs on the body

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A special type is innate drug intolerance. This term is now imply greater sensitivity of some patients to certain drugs used in the usual therapeutic and subtherapeutic doses. In the modern view, it is the result of congenital deficiency of certain enzymes - enzymopathiesthat disrupts the normal metabolism of the drug in the body. Congenital drug intolerance is often autosomal dominant trait inherited. Examples include patients with hereditary erythrocyte the deficit glukozo-6-fosfatdegidrogenaza. When taking medications with oxidizing properties, there is an acute intravascular hemolysis with subsequent renal failure.
This group of hereditary disorders should include drug idiosyncrasy - congenital genetically determined disorders of immune processes on the basis of which arise giperergicakie reaction from some medicines.
In recent years, produced a large number of biologically active chemotherapeutic agents, has sharply increased use of chemicals in the external environment. These factors cause such violations of immune processes in the organism, as allergic reactions, addiction and tolerance, lower resistance to infections, influence on inflammatory and healing processes. The most frequently immune processes suffer from antibiotics and sulfanilamides, cytostatic, hormone preparations and immunosuppressants.
Well studied in laboratory conditions, but is rarely diagnosed in the clinic kind of side effects of drugs - pathological effect on the cell, its function and division. Subspecies of this pathology is teratogenic and mutagenic effects, causing congenital malformations, carcinogenic effect which malignant cell growth, cytolytic activity when the drug selectively destroy individual cells of the body, causing cholestatic hepatitis, nephritis and nephrosis, hemolytic jaundice.
With the wide introduction in practice of hormonal means appeared medicinal complications arising from the impact on basic metabolic functions of the body. Hormonal regulation of vital processes is broken from receiving glucocorticoids, thyroid and other hormones, which are mainly inhibit self-regulatory mechanisms gormonoobrazovanii. A well-known fact of violation of potassium-sodium-balance under the influence of diuretic drugs. Most hypokalemia occurs, which is of significance for cardiac activity. Long-term anticonvulsant therapy (chloracon, primidone) causes deficiency of calcium and phosphorus, and this may lead to increased bone fragility. In some cases, the exchange functions violates the admission of psychotropic drugs, particularly neuroleptics.
New side effects of drugs that have arisen in connection with the widespread introduction of highly active antibiotics and other antimicrobial drugs, is also changing ecology of pathogenic and saprophytic germs in the body. The result is a medicinal effect on the balance of microflora of the person developing dysbacteriosis, superinfection and mycosis.