The effect of drugs on the body

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Currently (especially thoroughly clinicians and pharmacists) study the pathology caused by drug interaction when they are combined. Pathological reactions may be associated with impaired absorption, metabolism, distribution of drugs in the body and in places for the reception. When unwanted interaction of drugs decreases or increases their pharmacological activity and sometimes possible unexpected effects. Invalid combinations studied enough yet. However already now it is possible to say, for example, that include combination with monoamine oxidase inhibitors, tricyclic antidepressants and some antipsychotic drugs and food products. Tuberkulostaticescoy drugs isoniazidum some are very strict neurotoxic effects under the influence butadiona and weaken its therapeutic effects pyridoxine, nicotinamide and glutamic acid.
Complications do not always fall within the classification due to insufficient knowledge of their pathogenesis, layering effects of the underlying disease of the patient and in connection with the mixed nature of the clinical manifestations side effects of drugs. Mixed reactions for convenience of practical doctors can be identified in a particular type of drug pathology. Often toxic disguised manifestations of allergic reactions. In such cases, doctors difficult to differentiate these disorders, and they define it as toksikoallergicheskie. In these cases, moreover, the treatment one drug may cause toxic and other allergic reactions.
Speaking about the many remedies that are armed with our doctors, we cannot dwell on antibiotics. They still occupy one of leading places among the drugs that are powerful weapon intended to fight against many bacterial infections, surpassing in the effectiveness of all other chemotherapy drugs. Widespread in recent years resistant to antibiotics first generation (penicillin, streptomycin, tetracycline, chloramphenicol) and sulfonamides forms of bacteria-pathogens (staphylococci, gramotritsatelnyh bacteria) caused a reduction of their efficiency. New antibiotics is a semi - synthetic penicillins and cephalosporins, aminoglycosides, macrolides, fuzidin, lincomycin, and others - provide a high therapeutic effect (60-80% cases).
The complexity of the fight against modern infection explained not only by the increase of antibiotic resistance in pathogenic staphylococci and gram-negative bacteria to commonly used antibiotics, but also participation in inflammatory processes of conditionally pathogenic microorganisms (nesporoobrazuth gram-negative anaerobes from the group bakteroidov, and others), which has a natural resistance to most antibiotics. Among other factors, complicating infection control, it should be noted the increasing volume and complexity of surgical interventions, frequent instrumental examinations, the increase of the contingent of elderly patients, the widespread use of drugs oppressive immunological protection of the patient.
Some antibiotics first generation do not satisfy the requirements of medicine not only from the lack of activity, but also because of the high frequency of side effects. Currently, there is a possibility of choosing the best for the patient of the drug.