The effect of drugs on the body

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In connection with the creation of semisynthetic penicillins and tetracyclines gradually lose their meaning natural tetracyclines (tetracycline and oxytetracycline). Distinct advantages over natural tetracyclines have their semisynthetic derivatives - metatsiklina and doxycycline, which are more complete absorption and prolonged action. The possibility of using these drugs in smaller doses and with long intervals between wvedeniami (doxycycline once a day) causes a reduction in the percentage of adverse events in greater efficiency.
Indications for use of chloramphenicol sharply limited in connection with the development of serious complications. Chloramphenicol should be used in the Salmonella, CNS, respiratory tract infections caused by Klebsiella, and bacteroids. In a mixed aerobic and anaerobic infection, it can be combined with aminoglikozidami.
The basis of success of antibiotic therapy is a strong causal impact on the pathogen, individualization assignments. Detailed knowledge of the properties of the pathogen helps to choose the necessary preparation and install the optimal dose.
Rational use of modern antibiotics prophylactic and therapeutic purposes will allow to raise efficiency of the fight against common diseases.
In the decisions of the XXVI Congress of the CPSU, a series of decrees of the CPSU Central Committee and USSR Council of Ministers of exceptional importance to the further development of fundamental research for medicine. Among them is the knowledge of biochemical processes of vital activity of an organism. The basis of all physiological functions lies metabolism, the driving force of which are enzymes. It is known more than 2000 of these biological catalysts life processes.
The science of enzymes - Enzymology - has become a booming industry knowledge with numerous branches and sections. Among them, an important place belongs medical Enzymology.
The most important section of medical Enzymology is the use of enzymes, coenzymes and activators and inhibitors of enzymes in the clinic for treatment. Enzymatic drugs have long been used in substitution therapy, especially in low function of digestive glands. Drugs hydrolytic enzymes animal bacterial and plant origin, have become an integral component in the treatment of various inflammatory processes.
Wider area enzymotherapy - injecting use of highly purified enzyme preparations for therapeutic purposes.
Currently real for clinic is the use of enzymes in cases of their deficiency in the blood and other extracellular fluids. The Central problem is the use of enzymes and their activators for lysis of blood clots in blood vessels, blocked by blood clots is one of the main causes of mortality in coronary heart disease, diseases of brain vessels, limbs, and so on
As thrombolytic agents using drugs plasmin (fibrinolizina), proteolytic enzymes from actinomycetes (brynza, banalata), etc. But exogenous input enzyme immediately inactivated plasma inhibitors. In addition, possible serious adverse reactions. More promising was the use of plasminogen activators, facilitated by understanding the molecular mechanisms of natural fibrinolysis.