Lakopenia

Radiation - reduction of the number of leukocytes in the blood (less 5000-4000 ). Leukopenia occurs when typhoid fever, brucellosis, influenza, polio, epidemic hepatitis, malaria, leishmaniasis, and also with radiation lesions (see Radiation damage), aleikia, and aplastic anemia patients. Leukopenia occurs from certain drugs (amidopyrine, phenylbutazone, sulfa drugs, thiuragyl) in people with high sensitivity to them. The most frequent form and leukopenia neutropenia, including agranulocytosis (see), less often lymphocytopenia.

Lakopenia (leukopenia; from the Greek. leukos - white and penia - poverty, lack) - decrease in the number of cells below 4000 1 mm3 peripheral blood. Lakopenia can proceed with a uniform reduction of all forms of leukocytes, but often reduced to any one form of white blood cell that gives the basis to speak about neutropenia, lymphocytopenia, eosinopenia.
Radiation can be functional and organic. When functional L. bone marrow in his cell composition full, but functionally depressed. L. organic origin due cell failure of the bone marrow due hypoplasia granulocyte Rostock bone marrow, as well as its aplasia with the almost complete disappearance of myeloid elements. Functional L. arise in the hypnotic state, the General loss of tone, stimulation of the vagus nerve, starvation, brutal conditions, as well as acute and chronic infections (influenza, typhoid, measles, rubella, epidemic hepatitis, tuberculosis, syphilis, chronostasis, brucellosis and other); the toxic action on the blood (leukocytes) and blood-forming organs industrial chemicals (benzene, sodium fluoride, drugs DDT and other), and pharmaceuticals (amidopirina, phenylbutazone, antipyrine, 6-methylthio-uracil and other). To the group of functional leukopenia should include scarce L., emerging when malnutrition, insufficient intake of proteins, some amino acids, vitamins, etc. and immune radiation, depending on the presence in the blood of autoimmune antibodies and development processes leiko-agglutination and Lachaise.
The origin L. can be explained by a decrease in the production of leukocytes in connection with the violation of the process of differentiation, maturation and release myeloid elements of the seats of blood in the peripheral blood or increased destruction of cells and removing them from the body. A certain value in the destruction of cells belongs to the spleen. In the States of hypersplenism often develop "splenic" leukopenia. It should be mentioned radiation L. as a result of exposure to ionizing radiation, and "redistributive" L, is not accompanied by changes in leukocyte formula and a violation leikopoaiza in the bone marrow. Possible HP more complicated pathogenesis, when in the development of their participates several mechanisms. When L. organic origin prognosis is poor. L. as a manifestation of the functional state of peripheral blood may sometimes give the outcome in leukemoid reactions and be a harbinger of acute leukemia.
Treatment of Staphylococcus different origin is to eliminate the negative exogenous factors to stimulate leikopoaiza (pentauxil, steroid hormones), repeated blood transfusions, vitamin therapy (B6, B12, Pantothenic and folic acid, nukleinovogo sodium). When indicated should decide on splenectomy. Recently, master of auto - and gomotransplantation bone marrow.