Leukaemia after radiation exposure

Proof of leukemia with irradiation is the frequency of the disease among survivors of the atomic explosion, roentgenologists and radiologists, patients exposed to radiation for therapeutic purposes. Etiological role of ionizing radiation in causing leukemia shown in the experiments on different species of animals as in the case of external irradiation and when entering the body evenly distributed (Nb95, Cs -137, N3) and osteo (Sr89 and Sr -90, Pu -239 and other) radioactive isotopes.
Set a certain dependence of the frequency of occurrence of L. dose-dependent and mass irradiated tissue. Most authors recognize threshold character leukemogenic effect of radiation. As a threshold lead doses of 50, 100, 200 p. However, given the insufficient knowledge of this issue, the development of practical and organizational measures in the health care system come from a view of the absence of such threshold. For the occurrence of radiation leukemia need a certain period of time (latency period). The increased risk of Leningrad people is observed in the period from 2 to 10 years after exposure.
The clinical picture of radiation leukemia does not have significant differences from leukemia process other etiology. When exposed to radiation over the natural development of L. acute and chronic myelogenous leukemia. HP develops more often in the presence of last changes in the blood, characteristic radiation sickness, but can occur in people without a clear manifestation of this suffering. The pathogenetic basis of occurrence of radiation La is a violation of the processes of physiological regeneration very radiosensitive blood-forming tissues, with high opportunities for recovery.