Lymphocytosis acute infectious

Lymphocytosis acute infection (lymphocytosis acuta infectiosa; synonym asymptomatic acute lymphocytosis)- benign viral disease mainly children (from 1 to 14 years), characterized by giperlakotsitos at usual lack of or poorly expressed clinical manifestations.
The disease meets everywhere. Adults get sick very often. Describes numerous outbreaks in institutions for children, families and sporadic disease. Sometimes they reveal a mass blood survey. A biopsy lymph nodes find lymphocytes and lymphoreticular cells.
The incubation period is from 6 to 25-35 days. Most often hidden and deleted forms of acute infectious limfotsitoz who discovered by chance during the research of blood, feverish form, which occasionally accompanied by rise of temperature up to 40 degrees with significant deterioration of the General condition. Severe meningeal and entsefalicheskogo symptoms are rare. There may be catarrh of the respiratory tract, sore throat, diarrhoea phenomenon pain in the abdomen, mimic appendicitis, scarlatina - and crepadona rash, arthralgia and myalgia. Lymph nodes and the spleen is rare. During operations sometimes discover increase retrovirally lymph nodes. Total protein remains within the normal range, level reduced albumin, globulin level increased by beta-, gamma - and partly alpha-globulin. All these violations is very short.
The main determining the diagnosis symptom is a change of white blood - high leukocytosis (from 30 000 to 140 000). Dominated (80-90%) small lymphocytes with a dark pinnatisected kernel, oncoprotein. Meet lymphocytes medium and even large size, atypical lymphocytes, macrophage and lymphoreticular cells, bullock Botkina-Gumprecht. Part of lymphocytes - shirokodiapazonnyj with Auroville grain. The absolute number of eosinophils increased. The number of cells increases during 4-6 days, kept at the maximum level 6-10 days, and then without treatment decreases to normal or below with a subsequent rise to normal levels. The duration of the period of pathological changes of blood 14-30 days.
The differential diagnosis is carried out with regard to chronic lymphocytic leukemia, infectious mononucleosis, and toxoplasmosis. First children are extremely rare. He held a long heavy, enlargement of the spleen and lymph nodes, pathology red blood and the bone marrow punctate. Infectious mononucleosis occurs at high temperature, accompanied angina, lymphadenitis, especially cervical, occipital, enlargement of the spleen and liver, and the characteristic changes in the blood. Lymphonodular form of toxoplasmosis is determined using techniques that detect Toxoplasma, and serological and allergic samples.
The treatment is symptomatic. Apply ACTH, cortisol. Prevention is not developed. Some authors recommend to isolate the sick.