Lymphoepithelioma (synonym: tumor Since, epidermoid cancer of the tonsils) is a malignant tumor arising from epithelial reticulum epithelial mucous membrane of the pharynx in combination with its lymphoid elements. The peculiarity of lymphoepithelial is syncytial nature epithelial component. The most frequent localization of lymphoepithelioma - nose throat and tonsils; less common L. thymus gland and even more rarely - respiratory tract, thyroid, parathyroid and urinary tract.
Limfoepiteliomy occur mainly in men aged 30 to 60 years old, have the form of a polyp, hanging with nasopharyngeal localization in paranasal sinuses; such a polyp easily ulcerated and bleeds. Spreads L. in the lymph nodes of the neck, lung, pleura, the liver, the abdominal cavity; has infiltrating growth during germination of large vessels of the neck can give massive bleeding. Histologically epithelial component presents, in large cells with achromatic puzirkoviy kernel with nucleoli. Cytoplasmic processes of epithelial cells, touching each other, form reticulum, hinges which are lymphoid elements. Epithelial reticulum of lymphoepithelial different from mesenchymal reticulum of retikulosarkome ability to give glandular structure and cell groups singled out the whole syncytium. Among these cell groups sometimes appear flat cells with signs of keratinization.
Clinical symptoms limfoepiteliomy determined by its localization. When pharyngeal increased L. one of the tonsils, there are a sore throat, difficulty swallowing; nasopharyngeal - reduced hearing difficulty breathing; L. in the thymus gland revealed signs of tumors of the mediastinum. Duration of disease - from 1.5 to 2 years. The prognosis depends on the location.
Lymphoepithelioma nasopharynx more malignant course.
Most L. highly sensitive to radiation therapy, therefore shown radio - and radiotherapy.