Chronic lymphocytic leukemia

Chronic lymphocytic leukemia (synonym chronic lymphedemas) is characterized by the growth of lymphatic tissue, replacing normal bone marrow hematopoiesis, while the peripheral blood is flooded with lymphocytes. The disease develops gradually. You receive a modest increase in lymph nodes (at palpation , they are not very dense, mobile, painless), spleen and liver. In blood during this period reveal the increase of the total number of leukocytes and content of lymphocytes. Gradually the disease progresses - growing weakness, sweating, often fever, lymph nodes increase considerably. The increase in the mediastinum leads to the compression of the trachea and large vessels, which causes in patients with severe hacking cough, shortness of breath, sinus of the face, hands, neck. In these cases require immediate radiation therapy. The expansion of simpaticas nodes in the abdomen can cause compression of the stomach or intestines with symptoms of partial obstruction. Increase in varying degrees, liver and spleen. By progressive thrombocytopenia can develop phenomenon bleeding. During this period the composition of the blood characterized by anemia, more or less pronounced increase in the number of cells with absolute predominance of lymphocytes. The similar picture is in punctate bone marrow. The final stage of the disease is characterised by a marked depletion, recurrent pneumonia, fever and development of pustular and fungal infections of the skin and mucous membranes.
The diagnosis is based on the system swollen lymph nodes and relevant changes in the peripheral blood and bone marrow punctate.
Forecast in respect of life is poor, for benign disease patients 10 years or more can maintain working capacity.
Treatment of chronic lymphocytic leukemia in slow disease progression performed restorative means, good nutrition and vitamins. When deployed picture of the disease treatment in the hospital. In case of significant increase of lymph nodes, liver and spleen shown chemotherapy - leykeran (4-6-8 times mg per day), migranal (50-75-100 mg a day intravenously), when the local hyperplasia - and radiotherapy. Steroid hormones napochechnikov appointed only on the testimony: the accession of autoimmune hemolytic anemia, thrombocytopenia, increasing granulocytopenia for cytostatic therapy and so on, With the development astrointestinal and viral complications prescribe antibiotics.