Lipid metabolism

In the liver, the synthesis of pick and the breakdown of lipids. Morphological indicator of lipid metabolism in some diseases of the liver is fatty infiltration of the latter. As a biochemical test, allowing to estimate the functional state of the liver in the sphere of fat metabolism, can be used definition content in the blood of total lipids, phospholipids and cholesterol.
The total number of lipids in the blood serum of 300 to 800 mg%; a significant increase in their concentration is observed in liver disease accompanied by jaundice, especially in biliary cirrhosis, and also with mechanical jaundice (Popper, Schaffner, 1961).
Phospholipids are a form of transport of fat, their formation and splitting is carried out mainly in the liver; a large number of phospholipids excreted in the bile.
Liver damage causes an increase in the number of phospholipids in the blood, due to the violation of their excretion in the bile. The slight increase of phospholipids is observed at Botkin's disease, a stronger - up to 13-20 mg% (at the rate of 6-7 mg%) - liver cirrhosis (3. F. Denisenko, 1961); the sharp increase of concentration of phospholipids is typical for belitaza and biliary cirrhosis.
Cholesterol comes from food and synthesized by the body mainly in the liver. In the liver (to a much lesser extent in plasma and the wall of the small intestine) occurs and the formation of cholesterol esters, being the most recent in the composition of bile. The total amount of cholesterol in serum is 150-200 mg%, 2/3 of its esters.
When liver disease is a violation of the synthesis of cholesterol esters and, naturally, the decline in blood. The total amount of cholesterol is reduced only when severe liver damage (N. Starostenko, 1961). Increasing the amount of cholesterol in the blood is typical for diseases involving violation excretion of bile (mechanical jaundice, biliary cirrhosis).