The lipid profile

The lipid profile - graphics image of the quantity and quality of lipoproteins in the blood serum obtained by their electrophoretic distribution on paper.
The serum before electrophoresis (see) paint often Sudan black, identifying visually contained lipoproteins. On lipidogram there are three main areas. The first is in the area of alpha-globulins (alpha-lipoprotein), the second - in the field of beta globulins (beta-lipoprotein), the third - at the application serum tape filter paper (in the zone ' -globulin); in this last area lipoproteins not move under the influence of electrophoresis and called zero faction, or preoperatively (Fig). Faction lipoproteins because they are not strictly coincide with protein fractions, indicate figures I, II, III or letters a, b, C.
alpha-lipoprotein contain about 66% of the phospholipids and about 33% of cholesterol, beta-lipoprotein - cholesterol 56% and phospholipids 44%.
Preoperatively contain mostly neutral fats. Normally the content of alpha-lipoprotein - 13,0 for 29.3%, beta-lipoproteins of 34.6-50,3%, preliberation - 29,0-46,8% . Attitude

beta-lipoproteins/α ippopotami = 1,3-3,4.

The percentage of different fractions of lipidogram determine densitometrical by elution with subsequent photometry (see Photometry)and planimetrics. Of lipid can be used as an additional criterion for the differential diagnosis of diseases (acute hepatitis, cirrhosis, congestive jaundice and others), which are differentiated reduction α faction. The increase mainly In-faction observed in chronic hepatitis. Very characteristic changes L. when children nephroses, especially when lipid argued. The increase preliberation observed in atherosclerosis. Consider that a definition of preliberation can be used for mass examination of the population to identify the spread of the disease.
Cm. also Electrophoresis (electrophoretic study).

Proteinogram (I) and lipid profile (II) of the blood serum of healthy man. Proteinogram (III) and lipid profile (IV) of the blood serum of patients after myocardial infarction; p - 1 - pathological strip.