Lipoic acid

Lipoic acid (alpha-lipoic or thioctic acid) - 6,8-cityoklahoma acid.
CH2·CH2·CH(CH2)4·COOH
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S - S
Opened as a factor oxidation alpha-ketoacid in different microorganisms. Crystals lipoic acid - yellow plates, temperature PL 47,5°, [α]25D = 96,7 degrees. L. K. stable in dry form, in solutions in the light cures, poorly soluble in water, well, in solutions of alkalis, and organic solvents.
Biological role lipoic acid is involved in oxidative decarboxylation alpha-ketoacid (pyruvic and II) ketoglutarova). In enzymatic reactions involved L. K. associated with a protein by means of the peptide bond, which is formed between the group NH2 lysine and a carboxyl group L. K.
The administration of lipoic acid in the body contributes to the increase of consumption of pyruvic and II) ketoglutarova acids accumulate in certain pathological conditions.