Localizenewlines (synonym: interstitial calcification, localities, gout lime) - a rare chronic disease characterized by the accumulation of salts of calcium in the skin, subcutaneous adipose tissue, muscle, joint capsule and tendon sheaths in the absence of hypercalcemia. More often defeat restricted to any one part of the body, but it happens and universal.
Clinically, the disease is sometimes painful seals that on x-rays have the appearance of a clearly defined intense shadows. Watching two clinical forms of localizenewlines: muscle-chromatone (most of the defeat of the joint capsules) and subcutaneous (most of the defeat of subcutaneous fat). Muscle-chromatogra form may lead to the development of contractures, as the process is accompanied by gross scarring. When a skin forms the skin over the sites sometimes ulcerated, appear fistulas, from which stand out kroshkovatymi or pasty mixture of lime.
The deposition of lime in the lesions are preceded by dystrophic changes in the connection, fat or muscle tissue, which, in the opinion of Calender (O. Teutschlander), linked with local violations of cholesterol metabolism that develop due to disorders dancefloordance regulation. Hereditary constitutional nature of localizenewlines underlined by many authors. The disease sometimes develops after a skull injury or combined with various trophic (muscular dystrophy, osteoporosis) or hormone (impotence) disorders.
When muscle-chromatone form the process starts with uneven swelling and stanovily muscle fibers, mioplazmy which becomes homogeneous. Then in muscle fibers postponed lime, develop lipogenesis subject to further sclerosis and hyalinosis. After subcutaneous form first decomposition in the fatty tissues with the formation of lipogenesis. Then postponed lime, which is also accompanied sclerosis and hyalinosis. With the progression of the process due to necrosis significant areas affected tissue arise caverns containing tissue debris and lime mass. On the periphery of cavities growing granulation tissue with pockets of xanthomatose, which later becomes fibrous and hyalinized. Sometimes, after a break of cavities out fistulas appear.
Effective treatment exists. With limited forms of subcutaneous affected areas excised. Possible relapse.
Cm. also Calcification.