Locus minoris resistentiae

Locus minoris resistentiae (place of least resistance) - the organ, tissue, or system of the body, primarily subject to corruption in various diseases. The cause of locus minoris resistentiae may be age-related features of the organism (for example, diseases of the gastrointestinal tract in children for many infections), previous injuries and diseases of the organ or system, neuroendocrine disorders, and so on Locus minoris resistentiae often determines the localization of the pathological process, as the effects on the body primarily damage may be the body that are less resistant to the effects of pathogenic agent into force of the above factors.
For successful prevention, diagnosis and treatment are very important to establish locus minoris resistentiae.

Locus minoris resistentiae - the place of least resistance, i.e. the organ, tissue, or system of the body, primarily subject to corruption in various diseases.
Locus minoris resistentiae has a significant influence on the course of various diseases, including infectious, causing localization and peculiarities of pathological process.
Primary defeat of vessels of this or that body when arteriosclerosis, localization of infection (tuberculosis, syphilis, brucellosis and other) in certain organs, localization of skin diseases, etc., is largely determined by the presence in the body L. m. r. In the basis of Locus minoris resistentiae can be anatomic and physiological features of development agencies, violations servergehgusen and metabolic processes of the body, injury, occupational poisoning and long exposure to excessively low or high temperature, violations of the secretion of hormones and other common cause in the body L. m. r. - previous illness morpho-functional changes that may remain for a long time hidden due to the presence of compensatory processes.
Locus minoris resistentiae not always confined to any particular body, but can capture system tissues, regardless of their organ facilities. L. m. r. this kind occur, for example, when collagenoses. The mechanisms Locus minoris resistentiae essential trace response to the transferred irritation, pathologic reflexes (A. D. Speransky), on the basis of which new irritation of the body may lead to the resumption of the old, seemingly eliminated, the pathological process. So, for example, sagusa ulcer may recur when sick with the flu. Timely detection Locus minoris resistentiae is an important condition for the successful treatment of many diseases, in this connection special value gets a deep understanding of the attending physician with the medical history of the patient.