Leffler syndrome

Leffler syndrome (W. Loffler) - a disease characterized by inflammatory infiltrates, rich eosinophils in affected organs in combination with eosinophilia of blood. In 1932, this infiltration was written in a light, and later in other organs.
The true frequency Leffler syndrome is unknown, as it often gets overlooked. Different types Leffler syndrome unite similar etiology and pathogenesis. This is allergic diseases caused by different allergens. Especially often affects people who have other allergic diseases.
Conditions for the development of HP in different bodies are so dissimilar that their clinical picture is rather different. Almost completely harmless is eosinophilic infiltration of light (see). A positive flow and allergic eosinophilic pleurisy, independent or accompanying pneumonia.
Different in all respects picture HP in the cardiovascular system. He usually runs as parietal fibroelastosis endocarditis, striking the endocardium ventricles, much less the endocardium fibrillation and not affecting valves. The growth of collagen fibers of the endocardium and granulation basal layer and to the focal obozrenie adjacent myocardial join eosinophilic infiltration, lying mainly around the small vessels. Subsequent sclerosis endocardial covering his thrombotic masses and attack leads to the creation of an internal armoured heart and to the progressive without increasing the size of heart heart failure. The gap infected or uninfected particles of blood clots leading to death, and changes vessels cause softening of the brain, severe nephritis, etc., h.p. sometimes accompanies periarteritis nodosa.
Eosinophilic infiltration may occur in all departments of the digestive tract. Joining the enlargement of collagen fibers submucosal, they are formed mainly around blood vessels. So there is narrowing of the lumen of the body, leading to hypertrophy of muscle layer overlying Department, and sometimes to the phenomena of obstruction. In the x-ray and palpation picture of gastritis or enteritis simulates a malignant tumor and sometimes leads to unnecessary surgery.
Eosinophilic meningoencephalitis occur abruptly, with the expressed eosinophilia of blood and cerebrospinal fluid. When possible focal phenomenon on the part of the brain. The course is usually benign. Also flows, as a rule, HP, skin, liver, abdomen, genitals.
When all benign forms Leffler syndrome treatment unnecessarily. When prolonged or more serious forms resort to various anti-inflammatory drugs (corticosteroids, drugs calcium), antihistamines funds (Dimedrol, etc.,) and desencibiliziruta therapy. If possible, eliminate the existing allergen. Patients parietal fibroplastic endocarditis also give symptomatic agents and anticoagulants.