Radiation damage

Radiation damage - changes in tissues and organs, caused by ionizing radiation local influence.
Radiation therapy effects of radiation are not only amazed but also a certain amount of normal tissue, which under the influence of irradiation is developing the disease process, the extent and duration of which increases with the dose. At the end of radiation dose, tolerance for this type of fabric, which developed a pathological process regresses, leaving nerezko expressed traces atrophy and sclerosis. This degree of radiation changes conditionally called the local reaction to the irradiation. When irradiated in doses exceeding tolerance fabrics, develop radiation damage, irrevocable nature, which are considered as complications of radiation therapy. In the basis of radiation damage lies sclerosis and obliteration of vessels, degeneration of nerves and fibres, cell death parenchyma, atrophy of the tissues with the replacement galinadiamond connective tissue.
Radiation damage can occur when the radiation treatment of malignant tumors and benign diseases. More often they occur in radiation therapy of malignant tumors, which is explained by the necessity of exposure in high doses and short interval in the radiosensitivity of normal and pathological tissues, sometimes more radiosensitivity of normal as compared with the tumor tissue. A great role in the development of complications plays an improper planning of irradiation conditions, resulting in uncontrolled areas, exposed to high, intolerant for a given tissue dose.
Development of radiation damage contribute to repeat courses of radiation therapy in combination with surgical method due to circulatory disorders in the operated tissues, the accession of secondary infection, discharge from the wound, lubrication of the surgical field of iodine tincture and other, presence of concomitant diseases such as hyperthyroidism, diabetes, allergic States of any etiology, chronic inflammatory processes, and in more rare cases individually increased radiosensitivity of the patient.
Radiation damage can occur after exposure, several weeks after it, and in the later stages, after several years or even decades after exposure. Time of detection depends on the size and power of doses and fractionation. Short-term intensive radiation dose exceeding the tolerance tissue, causes radiation damage, developing in the coming days, with fractional irradiation or a single exposure in smaller doses, they occur in remote terms.
Radiation damage can occur under the influence of ionizing radiation from any source of radiation at a dose exceeding the tolerance irradiated normal tissue or organ. The depth of the lesion depends on the energy of the radiation and its penetrating ability. Beta radiation and soft x-ray radiation can cause damage of any severity, but in all cases it will be superficial, spectacular upper layers of the skin or mucous membranes. When exposed to radiation great penetrating power are damaged not only the skin and mucous membrane, but also the underlying tissues.
Severity of injury increases with increasing dose. At the same doses degree decreases as fractionation dose. Significant impact on the degree of the damage has age and General condition of the patient. Under the same physical conditions of irradiation of the lesion more children.
Currently known radiation damage of all without exception of human tissue.

Radiation damage (radiation damage) - changes of organs, tissues and systems of the body in the result of the action of ionizing radiation. May occur as a complication of radiation therapy (see), radiographers and radiologists in case of violation of safety rules, employees of the nuclear industry in accidents.
L. p. can manifest itself in different terms after exposure (see Radiation sickness).
To the total exposure of the body characterized by the development of acute or chronic radiation sickness. When local radiation effects, along with the General manifestations of the radiation damage can occur, and preferential L.P. those or other organs or systems which gets into the greatest exposure (see Skin, Bone, Blood, Lungs, bladder, Kidney, rectum, Radioepitheliitis, Egg from the Ovary).