Chlamydia

Chlamydia (synonym: Hodgkin's disease, malignant granuloma)is a system malignant disease characterized by tumorous growths in the lymph nodes, spleen, lungs, less often in other organs. Chlamydia can occur at any age, is more frequently among men than among women.
The etiology and pathogenesis of infection is still not clear.
Pathologic anatomy: the increase of individual groups of lymph nodes, spleen, rare liver. Histological examination of these bodies detects the expansion of the reticulo-endothelial elements, particularly characterized by the emergence of a giant with multi-core cells Berezovsky - Sternberg.

chlamydia
The patient suffering from generalized form of Hodgkin's disease.

The first manifestation of infection is usually enlarged lymph nodes, usually neck (Fig.). Later augmented and other groups of nodes; they become dense, are soldered to each other, but never nagnaivajutsja and not izyaslau. Increased spleen, liver. Appears fever (usually undulating with one-, two-week alternating periods of high and normal temperature), itching, weakness, weight loss, analizatze. Enlarged mediastinal lymph nodes can compress the trachea and bronchi, recurrent nerve, esophagus, large blood and lymphatic vessels. This is manifested by difficulty breathing, loss of votes due to paralysis of the vocal chords, a swallowing disorder, regional disorders of the blood and lymph circulation, etc.
For Hodgkin's disease usually of a chronic, progressive, much less often - subacute and acute. The death of patients is through 2-6 years from cachexia or impairment of the function of vital organs due to compression their enlarged lymph nodes.
Currently, early and rational use of radiation and chemical species cytostatic therapy provides an opportunity to cause long-term remission of chlamydia (up to several years), which significantly increases the life expectancy of patients (up to 10-15 years and more).
The diagnosis is based on a characteristic clinical picture and biopsy of an enlarged lymph node. Chest x-ray reveals enlarged lymph nodes in the mediastinum, and in some cases, the lungs, the gastrointestinal tract and bone system. In the study of blood find neutrophilic leucocytosis, hypochromic anemia, limfo - and thrombocytopenia (the latter may be the cause of hemorrhagic complications), eosinophilia and an acceleration ROHE.
To differentiate chlamydia have TB of the lymph nodes, retikulosarkoma, cancer metastases in lymph nodes.
Treatment. In cases with limited expansion of the lymph nodes conduct radiation therapy (see), sometimes with their pre-deletion; in a generalized process - chemotherapy (dapnom, dehradoon and others), always keeping the blood. Shown repeated blood transfusion, vitamins of group b, ascorbic acid, and significant anemia, leukopenia, or thrombocytopenia - corticosteroids.
Patients with Hodgkin's lymphoma contraindicated sun exposure and physiotherapy treatments. Cm. also Paragranum.
Skin manifestations with chlamydia can be specific and non-specific. The specific manifestations include rash, histological examination of which are changes that are characteristic of Hodgkin's disease and usually observed in the lymph nodes. Clinically they are characterized by nodules and infiltrates in the form of plaques of various sizes (singular and plural), thick consistency, as a rule, normal skin color, painless; the erythroderma (see) or single tumors with a tendency to ulceration, reminiscent of mushroom avium or lymphosarcoma.
Non-specific skin changes often simulate various dermatoses. These include: persistent, painful, difficult calmed itchy skin, accompanied excoriation (bruises as a result of scratching) and lichenification (thickening of the skin and increase its relief); rash pruriginous (pocesuha), urticarnae (blisters), bullous (bubble), scarlet feverand crepadona, a type of eczema, multiform erythema , and others. Histologically reveal banal inflammatory infiltrate. In the trophic disturbances are developing ihtiosiformnye changes: skin dryness, peeling, alvimarine (excessive keratinization of the epidermis), alopecia (see Alopecia). There are also violations of pigmentation, herpes zoster (see Herpes). The simultaneous existence of specific and non-specific rash. Skin changes with chlamydia often develop after the lymph nodes or simultaneously with them, but sometimes they can be the first symptom of the disease.

Hodgkin's disease (lymphogranulomatosis; synonym: Hodgkin's disease, malignant granuloma) - heavy common disease proceeding with tumor enlargement of lymph nodes, fever, itching of the skin and growing cachexia.
Chlamydia is a common disease; they are ill people of all ages, but more often men 30-50 years. Life expectancy is different: in acute for 8 to 10 weeks, subacute, - within the year, in cases of chronic average 3-5 years, rarely more than 10-15 years.
The etiology and pathogenesis. Etiology HP is still not clear. Numerous studies have not confirmed common in the first three decades of the 20th century the concept of tuberculosis etiology L. Some authors emphasize the etiological role of many other pathogens. Given that the morphological the essence of L. is the development of granulation tissue, L. trying to look as infectious-inflammatory process (M. A. Skvortsov). However, all morphological variants, meet with HP, characteristic of the tumorous diseases (I. Century Davydov).
In relation to the pathogenesis of L. no generally accepted and final conclusions. More often chlamydia considered by analogy with leukemia as a kind of blastomycosis process. X. X. Vlados and N. A. Kraevsky include L. to reticulatum proceeding with the expressed tumor growth. L. can affect all organs and tissues.