Minomycin (synonym carbonized) is an antibiotic from the group of macrolides, isolated from Streptomyces halstedii. On the chemical nature is weak base; forms stable salts of mineral acids, well soluble in many polar organic solvents. Has a comparative stability during storage at room temperature.
Antibacterial spectrum minomycin close erythromycin (see). The drug acts mainly bakteriostaticheski for many gram-positive bacteria and gram - limited. The presence of human serum no significant impact on the activity minomycin. A positive feature of minomycin is that to the action sensitive strains of bacteria resistant to penicillins, tetracyclines, polymyxin, streptomycin. However, strains resistant to erythromycin and oleandomitino, have, as a rule, resistance and M.
Introduction Meters per os and intramuscularly creates significant concentration in the serum for 4 hours. After a single injection of the drug persists in the blood serum of human 6-12 hour. The number of drug displayed with urine, is about 7-8%. In the cerebrospinal fluid M not penetrate, has little toxicity.
Minomycin shown with tonsillitis, infection of the respiratory tract, urinary tract, with an acute amebic dysentery, and also for skin diseases, caused by the representatives of the coccal group of bacteria. Especially effective in cases where strains of gram-positive bacteria were resistant to penicillins, tetracyclines, chloramphenicol and other antibiotics.
The drug is administered per os (at a dose of 2-3 g per day for 4-10 days) or intravenously (in a dose of 0.4 g every 6-8 hours after 24-36 hours). Side effects Feet slightly. Can be observed anorexia, nausea, vomiting, and sometimes a skin reaction. Cm. also Antibiotics.