Pages: 1 2

Medical treatment

To help a person to overcome drinking aims and medical therapy. On the basis of modern views on pathogenesis of alcoholism proposed a number of new drugs that allows you to arrest the pathological attraction to alcohol. We have already marked the leading role catecholaminergic systems in shaping major syndromes of alcoholism. Therefore, in the laboratory of the psychopharmacology research Institute on General and forensic psychiatry and VSC in medical and biological problems of narcology developed methods of treatment of alcoholism with stimulants dopamine receptors. Particularly effective was apomorphine and parlodel (parlodel) stimulants presynaptic dopaminovykh receptors in the Central nervous system. Interacting with receptors, these drugs suppress the pathologically increased synthesis of dopamine and therefore contribute to the inhibition of pathological attraction to alcohol and to address a number of irregularities in the structure of alcohol-withdrawal syndrome. Special techniques involve the use of encapsulated apomorphine and low dose parlodel (bromocriptine). The use of these drugs has not only medical, but also a preventive effect, since it prevents worsening desire to alcohol and relapses of the disease. Side effects when using drugs according to recommended practices not revealed. We are searching and other stimulants presynaptic dopamine receptors.
Identified and drugs that selectively affecting other catecholamine system nejromediatsii - noradrainergicescuu. With this purpose already recommended in the practice of public health drugs such as piroxin and clonidine.
Another system of nejromediatsii GABAergic also involved in the pathogenesis of alcoholism, works closely with the dopaminergic system and is with her in a reciprocal relationship (i.e., the increase in the activity of one system leads to a decrease in the activity of another). Consequently, during periods of exacerbation pathological attraction to alcohol and alcohol withdrawal syndrome (when the activity of the dopaminergic system is especially great) justified the use of means of stimulating the GABAergic system nejromediatsii. These tools include, for example, sodium oxybutyrate, phenibut.
It is promising and search tools, affecting one system to biogenic amines - serotonergic that increases the level of serotonin in the brain. According to Y. C. and N. Burova. N. Vedernikova (1985)that influence the serotonergic system, preparations endorphin and zimetidin today can be used as a means of suppressing pathological attraction to alcohol.
The attention of researchers attract and tools that affect the endogenous opiate system (involved in the modulation of the activity of the dopaminergic system). In particular, for edema craving can be used a tool to stimulate encephalomielitis activity. However, the development of such drugs in the future.
Today seems to be especially promising application in pathogenetic therapy of a completely new class of drugs - cortex - substances, secreted by the brain and highly selective action. One of the first compounds such proposed for the treatment of experimental alcoholism - the so-called "substance P"with a distinct sedative and antistress effect. In the experiment the use of "substance P" led to significant reduction of alcohol consumption.
On other principles based application in alcoholism neuropeptide lysine-vasopressin. Its use is based on the ability of lysine-vasopressin to improve memory in humans, optimize playback of traces of memory, to improve training. According to E. K. Pirogovo (1984), carrying out standard conditioned reflex techniques aimed to develop an aversion to alcohol, on the background of application of lysine-vasopressin has led to considerable improvement in the effectiveness of treatment.
Particularly encouraging the use of neuropeptide cholecystokinin. Apparently, this neuropeptide directly works in the centers of alcoholic motivation of the brain and reliably blocks them. This confirmed and conducted a study of drug action in the clinic. Set very high efficacy in relieving the main symptoms of alcohol withdrawal syndrome and acute pathological attraction to alcohol. Painful symptoms disappeared for a few hours and even minutes. Today, cholecystokinin is perhaps one of the most effective drugs used to relieve exacerbations of pathological attraction to alcohol.