Mercaptopurine (Mercaptopurinum; synonymous with lopurin; list a) - antineoplastic. Mercaptopurine, intervening in purine metabolism, violates synthesis of nucleic acids immature white blood cells and certain tumor cells. Mercaptopurine is prescribed for acute and sub-acute leukemia, chronic myeloid leukemia inside but 0,002-0.0025 g on 1 kg of patient's weight per day (2-3 receiving) within 3-4 weeks. If there is no therapeutic effect dose gradually increased to 0.005 g on 1 kg of weight per day. When adverse events (leukopenia, nausea, vomiting , and others) make a break in reception mercaptopurine. The form of release: tablets on 0.05 g
Cm. also Antitumor agents.