Methylene blue

Methylene blue (Меthylenum coeruleum; synonym: methylene blue, Methylenblau) - the main casinony dye. Used in histochemistry. Applied as antiseptic (see) in case of burns, piodermii, tinea (1-3% alcohol solution externally), with cystitis, urethritis and other inflammatory diseases of the urinary tract (washing 0,02% aqueous solution), and also when cyanide poisoning, carbon monoxide, hydrogen sulphide 50-100 ml of 1% aqueous solution, or 1% solution in 25% glucose solution intravenously; in the administration of nitrites, aniline, and others are used in small doses (0.1-0.15 ml of 1% solution for 1 kg of weight). Method of production: powder and capsules at 20 and 50 ml of 25% solution of glucose and 1% solution metilenovogo blue.

Methylene blue (Methylenblau; synonym: methylene blue, methylene blue; the formula C16H18N3SCl) is the main casinony dye. Crystals of dark green color with bronze Shine. Soluble in water and alcohol. Commercially available methylene blue is usually a double salt with chloride zinc. It is used as a dye in the textile industry; serves as a vital dye - intensive progresive some bodies a living organism, not others. Coverage M. S. at different pH values used in histochemistry for the detection and differentiation of nucleoproteins, mucopolysaccharides and mukoproteidov. When restoring M. S. discolored. This phenomenon underlies the method of Thunbergia for determining the activity of dehydrogenases. The essence of the method lies in the fact that hydrogen, otdalenii from oxidizable substrate in the presence of corresponding dehydrogenase, is transferred to M. S., on the degree of discoloration which is judged on the activity of the enzyme. In the presence of oxygen colorless form M. S. again easily enters painted. Cm. also Dyes.
Methylene blue as a drug. As a means of antisepsis methylene blue used externally (1-3% alcohol solution) in infectious medicine and burns, as well as in the form of 0.02% aqueous solution for periods when urethritis and cystitis. As an antidote, M. S. applied intravenously in the form of 1% aqueous solution, often 25% glucose solution (chromosme). In case of poisoning by carbon monoxide, hydrogen sulphide and others are introducing 50-100 ml of 1% solution M. E.; in case of poisoning methemoglobin forming substances (nitrates, aniline and other) - based 0,1-0,15 ml of 1% solution of 1 kg of body weight. The release form: powder and capsules at 20 and 50 ml of 25% solution of glucose and 1% solution M. S. See. also Antiseptic.