Microglobulin

Microglobulin (from the Greek. myxa - slime and lat. globulus - ball) is a disease of the vermiform process, and sometimes only the large intestine accompanied by the formation in their lumen mucous translucent grains or whitish beads (Fig. 1), reminiscent of grain sago, the diameter 0.1 - 1 see the Disease is relatively rare.

Fig. 1. Mucous balls when microglobuline.

Microglobulin vermiform process is also described under the name "the mucus appendicitis" as one of the rare forms of chronic appendicitis (see), proceeding with the obliteration of the proximal part of the process. Histologically in the vermiform Appendix note of changes characteristic of chronic appendicitis: granulating ulcers of the mucous membrane, focal atrophy her, scar fields and uneven muscle hypertrophy (Fig. 2). Often the process is concluded in spikes, his clearance stretched and made balls, then firmly seated on the mucosal surface, easily detachable from it at the opening of the Appendix. Education microglobuline grains associated with the peristaltic movements of the muscles of the closed process continued secretion of mucus glands; mucus under the influence of muscle contractions loses moisture and condenses in the soft touch balls. Mucous balls give a positive response to the mucus, histologically found layered structure of the ball, because the Central amorphous protein weight of cellular debris gradually acquires layers of mucus; among these layers are determined cellular elements: endothelial epithelium, leucocytes. There are known cases of mikroglobulina vermiform process proceeding and without obliteration of his crotch.
In newborns described microglobulin of the large intestine and the vermiform process occurred on the background of congenital malformation of the intestine. Histologically were marked's wrong developed restartovanie and shortened glands mucous membrane, as well as pronounced focal hypertrophy of muscle layers without anatomical impaired patency of the colon. Education microglobuline grains in these cases is explained by the presence of evil developed glands mucous membrane (Fig. 3)in the gaps which the mucus becomes stagnant and thickens.
From the point of view of congenital malformation can explain cases of mikroglobulina vermiform process occurring without focal obliteration of its clearance, the presence of diverticula, enlarged glands, muscle hypertrophy and violation of secretory and motor functions of the vermiform process.
Clinically microglobulin vermiform process does not differ from manifestations of chronic appendicitis, and, as a rule, can be recognized only if the operations undertaken over the last, or even in the study of the drug. Therefore, to wait too long operation in the diagnosis of chronic appendicitis is not necessary, as there may be cases punching walls process, which threatens the development of productive peritonitis. Trapped in the abdominal cavity mucus and especially the balls of her sumawinata, epithelial cells can be implanted in the peritoneum and continue mucus secretion, giving rise to the formation of pseudomyxoma peritoneum (see). Congenital microglobulin in children occurs with symptoms of partial or complete obstruction of the bowel.

Fig. 2. The wall of the colon with hypertrophy of muscle and corrupt developed a mucous membrane.
Fig. 3. Advanced gaps glands when microglobuline.