Mitomycin

Mitomycin - a mixture of several antibiotics and biologically inactive substances. Received in 1956 from the culture fluid Streptoinyces caespitosus. Selected mitomitina a, b, C (X), Y and mitomycin And-such fraction. The greatest activity has fraction of a and B. On the chemical nature mitomycin - based; mitomycin And has a reddish-purple color, mitomycin In purple. Mitomycin And received in the form of crystals rounded or needle-shaped forms. temperature PL faction And 159-161°, faction In 182-184 degrees. M. soluble in water and organic solvents - acetone, methanol, ethanol, chloroform, cyclohexanone, ether and others; poorly or not soluble in xylene, naphtha, petroleum ether and cyclohexane. Mitomycin And soluble in benzene, trichloroethylene and nitrobenzene, which mitomycin In insoluble.
Mitomycin, especially mitomycin And, broad antimicrobial spectrum of activity; high activity against gram-positive and gram-negative bacteria; weak active against fungi and yeast. In experiments in vitro M. possess antiviral activity (Newcastle disease, influenza virus) and activity against Ascaris.
Mitomitina have antimitoticescoy properties. The peculiarity of M is their ability to inhibit the growth of malignant tumor cells Kaposi Yosida and Ehrlich carcinoma. In the treatment Meters of mice infected with tumor cells above type, there is a great survival rate and lengthening of the life span. M. relatively highly toxic: in experiments on white mice LD50 for mitomycin a and b respectively 2 and 10 mg/kg Cm. also Antibiotics.