Muscle relaxants

Muscle relaxants (synonym relaxants) are substances, relaxing striated muscles, which leads to reduced motor activity or complete paralysis. Depending on the mechanism of action of muscle relaxants are divided into curariform means that violate the transfer of excitation from motor nerves in the muscles, and substances Central action. The latter include meprobamate (see). Muscle relaxing effect of these substances is mainly related to the depressing effect on the spinal cord. They have far greater latitude therapeutic action than curariform funds.
The ability to cause muscle-relaxing effect have also substances of doses and Central cholinergic antagonists.
Muscle relaxants Central action is used to treat a variety of diseases with a raise tone striated muscles: in spinal and cerebral paralysis with multiple sclerosis and other diseases of the nervous system. Muscle relaxants are widely used in anaesthesia (see) and the treatment of tetanus (see).
Cm. also Neuroleptic drugs, Holinoliticescoe funds.

Muscle relaxants (from the Greek. mys, myos - muscle and lat. relaxare - to reduce stress, to relax; synonym relaxants) - drugs that reduce muscle skeletal muscles with reduced motor activity until complete immobilization.
There are muscle relaxants peripheral and Central action. The former include curariform funds (see); they cause relaxation of striated muscles, breaking the transfer of excitation from motor nerves in the muscle.
Central muscle relaxants have a direct effect on the CNS divisions, participating in the regulation of muscle tone. On chemical structure of these muscle relaxants can be divided into three groups: 1) derivative glycerin (meprobamate, prendera, roxanol and others); 2) derivatives of benzimidazole (flexin and others); 3) mixed group (midokalm, STERIMAT, finality and others). The mechanism of relaxation of Central M. mostly related to the inhibition of the activity of the part of the neurons of the spinal cord; Central M. block polysynaptic reflexes and practically do not influence monosynaptic reflexes. Known value in the mechanism of action of the Central Meters has also oppression descending braking effect of the overlying departments of the Central nervous system (reticular formation, subcortically kernel) on segmental apparatus of the spinal cord. Some substances in this group along with the Central relaxing effect have other kinds of actions. So, meprotan (see) expressed atractions, and the midokalma - Central n-holinoliticescoe properties. Compared to curariform by the Central muscle relaxants have much greater breadth of action. It allows to use them for relaxation skeletal muscles without turning off the natural breathing.
Central Meters used in neurological practice in cases involving pathological increase in muscle tone and motor activity (spinal and cerebral spastic paralysis, Parkinson's disease, illness little and so on). In surgery, these substances are used for relaxing the abdominal muscles. When electroconvulsive therapy and tetanus Central Meters can be used for the prevention of post-traumatic complications.
From the group of Central M. the greatest practical interest, in addition to meprotan is midokalm (Mydocalm, synonym Mydeton; list B) hydrochloride, 1-piperidino-2-methyl-paratool-propanone-3. Applied inside tablets to 0.05 g 2-3 times a day; dose gradually increase to 0.1-0.15 g three times a day. The course of treatment 3-4 weeks; break between courses 2-3 weeks. The form of release: tablets on 0.05 g
Meprobamate and midokalm little toxic. In rare cases, side effect is drowsiness and headache. These phenomena are rapidly at lower doses of drugs. To reduce motor activity and reduce muscle skeletal muscles, i.e. as relaxants, use also the drugs belonging to other groups of neurotropic drugs (see.. Neurologiske funds, Holinoliticescoe funds).