Hereditary and constitutional factors

According to modern concepts among the factors that predispose to the development of peptic ulcer disease, is the role the Constitution and heredity. According to the data of different researchers, hereditary predisposition meets with different frequency and range from 15 to 40% (Lambert, Martin, 1969). Materials of N. I. Domracheva (1969), ulcers high incidence of parents and children than brothers and sisters of probands. Peptic ulcer disease in relatives of patients with localization ulcers in the stomach or duodenum occur with the same frequency. Obviously, peptic ulcer disease is inherited autosomal dominant. I. S. Zimmerman and M. A. sekzer (1968), L. And Geller and 3. P. Kozlov (1969) compared the clinical and laboratory parameters in patients with hereditary and without weights. It turned out that the number of indicators relevant to the possible mechanisms of development of peptic ulcer, only a higher level of acidity in the period of remission in patients with hereditary burden can be attributed to factors that contribute to more frequent and severe exacerbations of the disease. Fodor and others (1968) at the maximum histamine samples was observed in relatives of patients with peptic ulcer significantly higher acidity gastric content, than in healthy persons is Possible that the increase in the mass obkladochnykh cells in patients with duodenal ulcer in some cases, may have a genetic nature. The presence of hereditary predisposition determines the development of peptic ulcer disease at a younger age and a more severe clinical course.
Clinical observations in hereditary predisposition to ulcer disease led to a more in-depth study of the genetic characteristics in most of these cases, using modern methods of research. In this respect the significant importance of work on blood groups and secretion) antigens of blood groups with gastric juice, saliva.
Aird (1954, 1961) and many other researchers have found that in most countries people with 0 (I) blood group by 35-40% more prone to disease peptic ulcer with localization ulcers in the duodenum than those with another group affiliation.
In the Soviet Union, O. S. Radbil and employees (1969) showed that among patients with duodenal ulcer group 0 met significantly more often than in the control group of donors. At the same time the group And was often found at a stomach ulcer than with duodenal ulcer. Interestingly, regularities were more pronounced among patients who are taking place in the surgical Department, i.e. in case of a complicated peptic ulcer disease.