Neurophysiological changes

Experimental study of the neurophysiological mechanisms of formation of alcoholism focused research actions of alcohol on the emotional centers of the hypothalamus and motivational areas of the brain.
In studies T. M. Vorobyova with co-authors (1984) and L. N. Though (1985) the obtained experimental data, which, according to the authors illustrate the hypothesis of the involvement in the development of alcoholism system that organizes positive emotional behavior 1.
Data, Y. Volynkina, N. F. Suvorov (1984) suggest that the formation of pathological attraction to alcohol in patients with alcohol is carried out on the basis of the desire to experience alcoholic euphoria. According to the authors, the euphoria is not only activate a positive zone, but braking negative, in particular those within the system of negative reinforcement.
According to the conception of the Kronstadt Sudakov (1971), the desire to use alcohol based natural motivations on biological metabolic basis. Alcohol activates the appropriate centers, which in conditions of chronic intoxication can be reborn and become plasmaceramic pathological excitation. Was shown, for example, the possibility of the formation of experimental alcoholism based on the drinking of motivation (Cats, 1978; Kelesheva, 1980).
Positive results were achieved during the formation of experimental alcoholism-based defensive motivation. It is established, that after long periods of stress, change their properties defensive centers of the brain. Ethanol affect the metabolism of neurons centres, and its absence leads to disruption of the work of the centres and stimulates the search of possibilities of use of alcohol. It is not excluded the possibility to involve in the process of formation of alcoholism and other motivational centers.
Some authors (Statscan, Bandakar, 1986) is of great importance in the development of alcoholism give the effect of alcohol on the activities of the reticular activating system of the brain. The cerebral cortex is exempted from regulatory and inhibitory function that causes the feelings of the state of comfort.
The integral value of neurophysiological changes in the development of alcoholism is stable pathological condition (Bekhterev, 1974), supported by forming a matrix of long-term memory. Sedentary nature of such States of the brain is the cause of all future difficulties related to its functional correction.
Pathological system of alcoholism, uniting different stages of pathogenesis of alcoholism, includes a number of centres, generating pathological shifts on. different levels of the Central nervous system and all organism (Kryzhanovskii, 1980). Of course, not all the key aspects of pathogenesis known today. Yet it is difficult to understand the interaction between the different links in the pathogenesis of the disease. However, available data allow scientists to look at the main clinical manifestations of alcoholism.
So, the bulk part of the development of pathological attraction to alcohol and alcoholism as a disease are the changes in the systems of catecholamine nejromediatsii. And these changes thoroughly fixed in the functioning of the body. This rod strung next diverse pathological changes of metabolism at various levels: biochemical, immune, endocrine, etc. All of this reflects a forced restructuring of the body that can adapt to the conditions of regular use of alcohol. At the same time, after being committed in the metabolism of the body, falling, so to speak, in the "memory of the body", numerous pathological shifts with time and start to dictate the body preference alcoholic mode of existence.
Kind of alcoholic metabolism" of the organism, the patient alcoholism, once formed in a very small extent, is destroyed in the subsequent. Clinical practice suggests that any time the little touches complex pathogenetic developments in alcoholism, or they can to recover quickly. Although, having stopped drinking, the patient gradually passes close to doblestnom physiological functioning of the body, the risk of recurrence cannot be excluded and many years later. The main reason is the relative safety of the main pathogenetic links diseases, pathological substrate of alcoholism.

1. Found that alcohol activates most of the neurons in the lateral nucleus of the hypothalamus and oppressing activity ventromedial the kernel when the reciprocal nature of the relationship. Also found originally in the process of formation of dependence on alcohol is involved hypothalamus, then the hippocampus. Later joined by other brain structures: almond-shaped complex, related to the mechanisms of reinforcements and new crust.