New ways, new facts

For a long time it was believed that opujolevidnami viruses have strictly specific action. If, say, the virus causes kidney cancer in frogs, then he can only cause kidney cancer, and no other body, and only frogs, but not from any other animal. This view is very limited opportunity to study human cancers.
In fact, if these tumors are caused by viruses, these viruses infect only humans, then experiment with them on animals impossible. But it turned out that the idea of strict species specificity of viruses that cause tumors, inaccurate. Indeed, there are viruses with this specificity, but there are others that can cause cancer of different organs and different animals.
Particularly interesting was the virus, opened in 1957, two American researchers Stewart and Eddie allocated to them from cancer of the parotid glands mice. He was able to call 23 different tumors in four species of animals - mice, rats, hamsters and rabbits. Consequently, there are viruses that can infect a variety of animal species. Maybe these are the viruses that cause tumors person?
Now there is reason to think that this is true, at least for some of them.
In different countries were made successful attempts to transfer blood cancer (leukemia) human animal. Large studies have been conducted in this direction Century M. Burgholzer in our country. He managed to cause leukemia in mice inoculation them cell-free material from leukemia patients. The illness can be caused by a virus-like agent, and similar experiences are evidence of viral nature of cancer in a person's blood.
But there always is a virus in the tumor in such a state that it can be identified? We already know about masked viruses deprived of virulence. It turned out that the virus can stay in the cells and in the other state in which they cannot allocate conventional methods. What is this condition?
Viruses that infect bacteria, called bacteriophages (eaters of bacteria), or simply with phages. If the phage be added to the culture of the relevant bacteria, they dissolve. Every particle of phage consists mainly of protein and nucleic acids. In bacterial cell penetrates nucleic acid. It induces the synthesis of new phage particles, and the cell when it falls apart, as if dissolved, and the phage easily found in dissolved bacterial culture.
But sometimes when interacting phage and bacteria is another process. Nucleic acid, extending into bacterial cells, does not cause the synthesis of new phage particles. It remains inert and phage in such a culture to detect by conventional methods fail. But is it possible in this case to make nucleic acid to do her usual matter and cause the synthesis of phage particles? One of the most interesting facts proved by the fact that some impacts that cause cancer, such as ultraviolet or x-ray irradiation, was able to "activate" nucleic acid. In irradiated culture began to form new phage particles, and culture have disappeared.
Nucleic acids other viruses, both vegetable and animal, was also able to call in their respective sensitive cells synthesis of viral particles with fully pathogenic properties.
Thus, in the cells can be stored nucleic acid of the virus, which only under certain conditions begins to synthesize pathogenic viral particles, and to detect this nucleic acid virological or electromicroscopic methods is not yet possible.
Is there something similar in cancer man and animals?
Such an assumption has serious grounds. Moreover, it has already some experimental confirmation. Nucleic acids, allocated from the tissues affected by blood cancer (leukemia) people, was able to cause a similar disease in mice. This is only the first steps in an entirely new field of study of the causes of cancer, in which not only virological and biochemical techniques play a critical role. In the coming years, these methods will undoubtedly receive widespread use and enrich Oncology new facts.
However, now it is clear that the interaction of viruses, including opujolevidnami, with cells of the body is a complex, multifaceted process, single phase, which is still far not been studied.
Experimental Oncology now moving forward at a fast pace. New methods, which are still under development, have led to the discovery of new facts. These methods will be improved, and their use will bring us to that already near time! when will be solved the mystery of cancer.

  • What causes the tumor?