Oleandomitin (Oleandomycinum phosphoricum; list B) is an antibiotic used to treat infections caused by susceptible gram (staphylococci, streptococci, pneumococci, wand diphtheria and other) and some gramotricationah (gonorrhea, meningococci) bacteria, as well as by Rickettsia and major viruses. In clinical practice, using hydrochloric acid and phosphate salts oleandomitsina. Assign inside of 250,000 U 4-6 times a day. Higher doses: single 0.5 g daily 2, When taking oleandomitsina sometimes there nausea, vomiting, diarrhea, allergic reactions. The drug is contraindicated in the event of individual intolerance. The form of release: tablets on 0,125 g (125,000 U) and 0.25 g (250,000 U).
Cm. also Antibiotics.

Oleandomitin (synonym Domicil) is an antibiotic related to the macrolide group dedicated Sobin (C. A. Sobin, 1954) from cultural liquid aktinomiceta St. antibioticus.
Operates mainly on gram-positive bacteria (cocci, pathogens diphtheria, anthrax), rickettsiae, large viruses, some of the simplest. On gram-negative bacteria is not valid (exception Neisseria, Hemophilus Brucella).
On the antibacterial spectrum of action oleandomitin close to erythromycin (see).
Resistance of microorganisms to O. develops in vivo very slowly. Among laboratory strains is a cross-resistance to O. and other members of the group of macrolides. Among strains, freshly isolated from patients, such a pattern is missing. Oleandomitin has no cross-resistance to penicillin, tetracycline, streptomycin, chloramphenicol, polymyxin. In a joint application Acting with tetracycline observed sinergijnoj action, which helped to create a combined drug oletetrin (sigmameter).
Acting quickly absorbed in the introduction as per os and parenteral. The maximum concentration Acting in the blood is within 2 hours from the moment of introduction. Antibiotic accumulates mainly in the liver, kidney, spleen and lungs. The drug is excreted mainly with urine, and less with bile. The acting is low toxicity.
Side effects during treatment with oleandomitina practically absent.
In clinical practice, using hydrochloric acid and phosphate salts O. and his acetylated derivatives (for example, triacetonamine). O. assign inwards intravenously and intramuscularly with pneumonia, diphtheria, scarlet fever, sore throat, laryngitis, otitis, sepsis, septic skin lesions, infections of the urinary and bile ducts and other Average single dose O. when administered to adults is 250 000 UNITS, the highest single -500 000, the highest daily - 2 000 000 UNITS in 4-6 receptions. The highest daily dose for children up to 2 years - 20 000 UNITS per 1 kg of body weight; from 2 to 6 years - 250 000-500 000 UNITS, from 7 to 14 years - 500 000-1 000 000 IU, over 14 years - 1 000 000-1 500 000 UNITS. Intravenous O. enter on pyrogen-free saline solution or 5% glucose solution with the concentration of antibiotic no more than 2000 IU/ml of the Preparation to enter the drip method. Daily dose of 1 000-2 000 000 000 E. D. With intramuscular injection as a solvent use 1-2% solution novokaina - 1.5 ml per 100 000 IU antibiotic. Adult dose of 200 000-250 000 IU every 6 to 8 hours.
Contraindications to the use oleandomitsina - individual hypersensitivity and intolerance.
Cm. also Antibiotics.