Oncological aspects of endometriosis

Lighting genital and extra genital endometriosis would be incomplete without consideration of oncological aspects of the disease. If 15-20 years ago, they were reduced to the possibility of malignancy endometriosis and coexistence it and malignant tumors of the genital organs, but in the last time are more complex and deep. Background presented in the monograph B. N. Baskakov (1966).
The possibility of malignancy endometriosis at anybody does not cause doubts. However, information about this are very contradictory. Filed R. Meyer (1930), R. Hanser (1936), S. Viars (1955), B. I. Zheleznov, and A. N. Strizhakova (1985), the malignancy of endometriosis seems to be rare. On the other hand, G. Smith (1937) in 22% of differentiated carcinoma of the ovary has established communication with endometriosis. According to Century Czernobilsky (1970), the incidence of malignancy endometriosis and coexistence it and ovarian cancer reach 23.9 percent. A. E. Kolosov (1978) observed malignancy of endometriosis, ovarian 11.4 %.
Ya Century, Bohman, B. N. Baskakov, A. E. Kolosov (1979), paying attention to the difficulty of addressing the parsed issue, pointed out that the sequence of events during malignization of endometriosis clearly acts only in an early stage of cancer, when it is possible to trace the entire gallery of structures from endometriosis to invasive endometrial cancer. With further growth of the tumor can be completely occupy the land on which it originated, and "absorb" tissue that preceded it. In addition, full transformation of endometriosis in cancer patterns. So Ya Century, Bohman (1972, 1978) reasonably believes that the frequency of zlokacestvennoe endometriosis, apparently, far exceeds recorded in the literature.
Accumulated evidence of an increased tendency patients with endometriosis to neoplastic processes in the breast, endometrium and ovaries. Filed C. L. Vinokurov (1987), at the edge endometrioid cystadenoma ovarian every 10 patients (10,3%) are primary multiple metachronous tumors (cancer of the endometrium and breast), which testifies to the generality of the pathogenesis of these tumors and the need for a focused examination of patients to obtain a picture of the state of the endometrium and breast.
A. Century Chirkova (1980) among 150 patients with cancer of the cervix in 28 women (19,6%) has established its combination with internal endometriosis cancer.
According to Y. Century of Bojmana, V. P., Baskakov, A. E. Kolosova (1979), the study of the myometrium and endometrium in 140 patients with cancer of the uterine body enabled to detect endometrial hyperplastic processes in free from the tumor location in 72,1 %, fibroids - 55.7 % and internal endometriosis - 17.8 % (25 patients). B. N. Baskakov, et al. (1981) of the 84 patients with cancer of the uterine body in 14 (16,6%) found the internal endometriosis.
Endometriosis patients and cancer of the uterus and mammary glands are anovulation, endocrine infertility, immune system dysfunction, disorders of fat and carbohydrate metabolism, hyperplastic processes in mammary glands.
Research A. E. Kolosova (1985), the dependence of the forecast from the histological structure of ovarian endometriosis. So, the tendency to proliferation and malignancy more pronounced in glandular-cystic version. Glandular, cystic and stromal options are more favorable course. Shows a wide gistogematicheskie potency ovarian endometriosis, subject to certain conditions, has the ability to become a ground for all tumors endo-metrienas groups: adenomasand adenocarcinomas, malignant adenovirus, stromal sarcoma and mesoderm mixed tumors of the ovaries [Kolosov A. E., 1985].
Endometriosis patients are more likely to develop colon cancer, and stomach, especially if these bodies have been compromised (chronic spastic colitis, gastroduodenitis, peptic ulcer disease of the stomach) and sick for a long time were treated progestin or estrogen-gestagennoe drugs.

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