Features tumors in children

Tumors in children occur relatively frequently, in 5-7% in relation to all surgical diseases. Dominated by benign tumors, their correlation with malignant approximately 9:1. Malignant Acting in children usually mesoderm origin, whereas in adults - epithelial. In this regard, the children are more common sarcoma and extremely rare cancer.
Acting in children occur in all age groups, starting with the neonatal period. In most cases, they occur at birth or in the first months and years of life, usually under the age of 5-6 years. O. affect girls more often than boys (in the ratio 3 : 2).
Different types of tumors that seen in adults, there are also children. However, there are neoplasms, peculiar only to the children's age. These O. find a number of features.
In etiology and pathogenesis of Acting in children plays a big role vicious development rudimentary, improper location of cell groups different embryonic leaves. Thus, a significant part of vascular tumors, which are the most common and characteristic tumor of childhood, is a malformation type hamartoma. Some authors consider that the most specific to childhood are Acting, developing soil anomalies, i.e. Acting dysontogenetic origin. I believe that the deviation from the normal development of the kidneys may serve as a ground for the emergence of Wilms tumor (see Wilms ' tumor). Thus, the children a number of tumors is on the verge of malformation and true neoplasms.
The peculiarity of Acting in children is their development of immature tissue. In some cases, the differentiation of so few expressed that cannot be set from which embryonic leaf is About.
Histological pattern of some immature tumors in children reflects not malignancy, and only insufficient maturity of tissues and sometimes such a kind that does not even allow to distinguish the cells of the connective tissue of origin from epithelial. This makes it extremely difficult morphological diagnostics Acting in children.
The clinical course of many Acting in children also has its own peculiarities. For example hemangioma, being on histological structure benign, at the same time, rapid infiltrating and sometimes destructive growth resembles a malignant tumor. Describes neuroblastoma who benign course because neuroplasty can become Mature and differentiate into Mature ganglion cells. Melanoma in children clinically benign, and after puberty becomes malignant course. Adenosarcoma kidneys (Wilms ' tumor), being encapsulated in a long time does not show itself, there is "dumb". Teratoid tumors, consisting of Mature tissues, can metastasize. Although some Acting in children, built from immature cells clinically benign, they should be treated as potentially malignant, as they can always be malignities.
Thus, children border benign and malignant phenotype O. less pronounced than in adults, and often blurred.