Psittacosis

Pathological anatomy. At the opening died of psittacosis in cases not complicated by secondary bacterial infection, detect viral or so-called atypical pneumonia. Light increased in weight; groping in them define multiple foci seals, most of lobular or drain, sometimes seals grasp the whole of the share. The surface of the cut dark grayish-red color, in some cases with a violet tint; when pressing of them abundantly expires sero-bloody fluid. Histological examination part of the alveoli in these pockets of air, others made serosanguineous liquid or contain fibrin and a large number of cells. Capillaries worthwhile, sometimes they marked clots. Alveolar walls were thickened due to the proliferation of cellular elements, infiltration by mononuclear cells. For pneumonia when psittacosis typically absolute prevalence of sero-fibrinous exudate mononuclear with almost complete lack of polymorphonuclear leukocytes. Often in the cells of the alveolar epithelium find rounded or oval basophilic cytoplasm inclusion in diameter from 1 to 3 microns, representing elementary bodies virus psittacosis. They CHIC-positive and stained positively for DNA on Valgene. The connection of a secondary bacterial infection is accompanied by the appearance of purulent destructive necrotic bronchitis, hemorrhage and abscesses.
In the CNS find a plethora, swelling and petechial hemorrhages. Sometimes celebrate small necrotic foci in the white matter of the brain due to capillary thrombosis, as well as diffuse soaking Pia mater gelatin the exudate containing mononuclear cells. The liver is often increased, histologically determined protein, fatty and focal necrosis of the liver cells. Kuperovskaya cells often contains clusters of elementary Taurus virus. The spleen is enlarged due to hyperemia and hyperplasia of reticuloendothelial. Regional in relation to the lungs, lymph nodes are enlarged, swollen, swollen, with symptoms lymphoreticular hyperplasia. In the heart muscle - dystrophic changes, occasionally small hemorrhages, in some cases, swelling interstice to the accumulation of large mononuclear cells. Small haemorrhage may be identified in the pericardium, as in other serous membranes, on the mucous membranes and skin. In individual cases, the presence of a sero-fibrinous of pericarditis. In the kidneys, in addition dystrophic changes convoluted tubule epithelium and expressed hyperemia, microscopically sometimes reveal the capillary thrombosis individual glomeruli and hemorrhage. To differentiate morphological changes of the lungs at psittacosis from observed in other viral and riccetsios processes (q fever) is very difficult. This task is made easier by identifying elementary Taurus virus psittacosis, stainable method Romanovsky, etc. To detect Taurus virus it is also advisable, except sections, smears-prints from the lungs, liver, spleen, brain.
Pathogenesis. The causative agent, who has entered the body through the mucous membranes and damaged skin, is found in the blood more constant to the 8-th day of illness. Later the frequency of its allocation is sharply reduced. The causative agent through epitheliotropic is fixed in the cells of the brain membranes, bronchi, lung, urinary tract, kidney, secreting cells tubules liver and bile passages and cells of the reticuloendothelial system. Repeating the cycle of development of the pathogen is accompanied by a violation of cell metabolism, intoxication and allergic restructuring. The release of the body of the pathogen occurs under the influence of immuno-biological factors. The causative agent is allocated with sputum and, apparently, with the urine and feces.
The immune system. Transferred disease leaves short and expressed little immunity. Re disease through periods calculated in a few months, often observed. The leading role in the immune system belongs humoral and especially cellular factors of protection. When psittacosis formed agglutinin, complementative and neutralizing antibodies. Phagocytosis in protecting the body is likely part of a limited role, as the causative agent, captured by leukocytes, not he is neutralized.