Pathological anatomy of acute pancreatitis

Morphological changes in acute pancreatitis has been studied mainly in severe forms of the disease. They are inflammatory changes, necrosis, and further atrophy, fibrosis and calcification of the authority.
In the initial period of the disease is detected diffuse or focal gland swelling, combined with Unsharp pronounced symptoms of focal necrosis and inflammation.
Further develop severe vascular and extravascular destruction, giving more pronounced diffuse or focal hemorrhagic and fat necrosis, edema and inflammation. This may result in subsequent festering with the formation of multiple small or large abscesses, sequesters body and false cysts.
When hemorrhagic necrosis iron is increased, tabla soaked in blood due to heavy bleeding. Often dominated by small hemorrhages, but there may be large. Histological examination found edema, extravasate, foci of necrosis.
When fat necrosis on the surface of the gland can see various size and shape grayish spots. Similar spots are identified on the seal and the peritoneum. Histologically in the areas of fat necrosis of the tissue of the body destroyed and represents the detritus accumulation of calcium Soaps, crystals fatty acids. Around areas of necrosis tissue of the gland swollen, contains inflammatory infiltrates and extravasate.
At purulent pancreatitis prevail phenomena purulent inflammation with the formation of various sizes abscesses or widespread melting of glandular tissue. In case of a favorable outcome is developing fibrosis body.
In milder forms of the disease morphological picture appears swelling and mild severe inflammatory changes.