Poisoning with carbon monoxide

Carbon monoxide - carbon monoxide (CO) is formed by incomplete combustion of substances containing carbon. In pure form WITH is a colorless gas that is slightly lighter than air and has no smell. Practically CO-occurs in a mixture of different gases. Acute poisoning by carbon monoxide found in industry and in private life. In a life of poisoning as possible accidents with injuries gas pipelines in gasified apartments, at inept using gas network or stove heating, fire, gunpowder explosions, personal garages and other Famous cases of poisoning with carbon monoxide with the purpose of suicide.
Proceeding through the lungs into the blood, it binds to hemoglobin, forming a very strong connection - carboxyhemoglobin. The affinity of carbon monoxide to the human hemoglobin about 300 times higher than that of oxygen. Therefore, even small concentrations can lead to the formation of blood significant quantities of carboxyhemoglobin. Hemoglobin associated with carbon monoxide, loses the ability to connect with oxygen, which violates the access of oxygen to tissues and organs, leading to the development of oxygen starvation. The severity of the poisoning is determined by the degree of saturation of her blood. When the binding of carbon monoxide with 60-70 % of hemoglobin death can occur. There is considerable individual variations to the toxic effects of carbon monoxide. Women suffer intoxication easier than men. There is also increased resistance to carbon monoxide in children under one year of age compared with adults.
There are several forms of poisoning by carbon monoxide. Fulminant form comes from exposure to extremely high concentrations of carbon monoxide. This form is characterized by a momentary loss of consciousness, single spasmodic contractions of muscle groups, and a quick stop breathing. Death in its form resembles apoplectic stroke. It should be borne in mind that in such cases the carboxyhemoglobin can only be detected in the blood of the cavity left ventricle of the heart and thoracic aorta, where he is in very high concentrations (80% and higher). Slow form may have a different period - from light to heavy. Appear muscle weakness, especially in the legs, dizziness, noise in the ears, nausea, vomiting, lethargy, drowsiness, sometimes, on the contrary, violence, loss of orientation (picture poisoning resembles alcoholic intoxication). In process of increase of intoxication come disorder coordination, persistent loss of consciousness, convulsions, delirium, hallucinations, coma. Death from paralysis of the respiratory center. The heart contracts still 2-8 minutes after stopping breathing.
Be aware that death may follow after 1-3 weeks after the poisoning due to vascular disorders and hypertension in the basal ganglia, oblong brain infarction.
Diagnosis is based on the circumstances of the accident, laboratory data, characteristic clinical picture, data - mortem (the color of a dead spots and blood) and data forensic chemical examination (determination of carboxyhemoglobin in the blood of a corpse).