Acute poisoning drugs means

Poisoning drugs are observed in everyday life when unjustified increase their doses in cases of self-treatment, abuse, and when you receive them by suicide motives. When taking certain pills (for example, tranquilizers) notes enhance the effect of alcohol. The most common is the administration of barbiturates - derivatives of barbituric acid: cyclobarbital, hexobarbital, barbanel, phenobarbital, teminal-sodium, barbitala-sodium. Among hypnotics nebarbiturovye of a number of more common poisoning exiroom, oxybutyrate and some other drugs.
Picture of poisoning drugs in adults largely depends on the dose of the drug and its mechanism of action, combination of therapy with other tools that enhance their action, as well as from individual reactivity of organism. Already admission of barbiturates in doses exceeding therapeutic (hypnotic) 3-4 times, comes mild poisoning. The adoption of 15-20 times the dose of the drug causes very severe poisoning, often ending in death. Dose of 0.1 g per 1 kg of body weight fatal. Analgesics, neuroleptics and other neurotropic substances increase of sleeping pills. Most sleeping pills enters the body orally, the number may be injected parenterally (barbitala-sodium, barbanel, atminas).
Barbiturates are very quickly absorbed from the stomach. After 8 h they are not detected. The mechanism of action of barbiturates is reduced to a deep ugnettemu influence on the Central nervous system and is accompanied coma, the oppression of the respiratory and vasomotor centers, development of hypoxia and other symptoms. At showdown signs quickly coming death, and certain changes in the various divisions of the brain. Quantitative detection of barbiturates in the biological environment of the organism allows to determine the degree of intoxication and diagnose death by poisoning them. On judicial-chemical study are sent blood, urine, cerebrospinal fluid. The development of acute intoxication occurs when the concentration of poison in the blood of 1 to 10 mg per cent, depending on the nature of the substance. The content of barbiturates in urine does not depend on the stage of intoxication. On judicial-chemical investigations in cases of acute lethal poisonings should be addressed to the washing water of the stomach, urine, blood, and cadaveric material. Barbiturates long stored in a human cadaver. For example, barbanel find 6 weeks after the death, and in a human cadaver, canned formalin, - in 3 years. Acute poisoning drugs nebarbiturovye stimulants, mainly derived piperidine (exeron, sodium oxybutyrate and others), remind him of poisoning barbiturates. Toxic dose of oxirane varies in wide range - from 5 to 20 g (20-80 tablets). Noxian slowly absorbed in the gastrointestinal tract and thus the symptoms of intoxication may occur several hours after admission. The drug has deposited in fatty tissues, slowly eliminated by the kidneys. In toxic doses causes pronounced dampening effect on the Central nervous system until the development of severe coma. Pathomorphological changes are the same as in the administration of barbiturates. The diagnosis of acute poisoning is made on the basis of the circumstances of the accident, the clinical picture and data forensic chemical examination, where is the quantification of drug in the blood and urine.
Systematic introduction to the body of rape as barbiturates and nebarbiturovye, can lead to substance abuse and addiction, characterized by similar symptoms of physical dependence from drugs. As agents causing substance abuse, barbiturates more dangerous than other hypnotics. As a result of increased tolerance to the maximum dose of barbiturates can reach 4,5-5,0 g