Poisoning with poison, causing tissue destruction

To destructive poisons include a group of substances whose effect on the organism occurs mainly in violation of the structure of the internal organs in the form of dystrophic and necrotic changes of the kidneys, liver, heart, gastrointestinal tract, brain, and other Mechanism poisons of this group is largely dependent on ways of introduction, of the physical state of the substance, as well as the state of the body. Many of them have as resorptive and local irritating property, which is manifested in the mucous membranes of the digestive tract. A number of poisons this group accumulates in the body when exposed to small doses (accumulation), and therefore the judicial doctors have to deal with cases of chronic poisoning by these substances.
The group of these toxins, including heavy metals, metalloids, and many of their connection.
Local action destructive poison often irritating or cauterizing. The main Toxicological significance of changes in the body, coming under the influence of resorptive poisons. The overall effect of these poisons can be manifested in the defeat of the Central and peripheral nervous system (paralysis, encephalopathy); violation of the activities of neuro-regulatory mechanisms, blood vessels, and the destruction of organs and tissues (heart, liver, kidneys and other).
Connections of heavy metals and arsenic act on certain groups of physiologically active enzymes. The decreased activity of various enzymes and largely determines the nature of General toxic action of these compounds. In severe poisoning, notably suffer all kinds of currency and especially the carbohydrate and protein. All these poisons along with violations functions of the nervous and cardiovascular systems and changes in metabolism have a pronounced nefrotoksicski action.
Some compounds of heavy metals and arsenic (copper sulphate, arsenic hydrogen and other) cause hemolysis, which is the leading characteristic in the first hours and days of intoxication these poisons.
From poisoning by heavy metals of the greatest importance poisoning by mercury compounds, and of poisoning metalloids - poisoning compounds of arsenic. Other poisoning - phosphorus and its compounds zinc and its compounds, sodium fluoride, copper sulfate - in forensic practice are very rare.

1. What is the mechanism of mercury and its compounds in the human body?
2. Describe the clinical picture of poisoning by mercury and its compounds.
3. What is the basis for forensic medical diagnosis of death from acute poisoning by mercury and its drugs?
4. What is the mechanism of action of arsenic and its compounds in the human body?
5. Let clinical characteristics of poisoning by arsenic and its compounds.
6. From that comes the death by poisoning compounds of mercury and arsenic? What is the lethal dose of these drugs?
7. What is the basis for conclusions of the forensic medical expert of the occurrence of death from acute poisoning compounds of arsenic?