Infringement of oxidative processes

Immediately after extensive burn the animal on the increase of gas exchange: increases breathing and increases oxygen consumption by 160% and more from the original norm. However, 20-30 min. total consumption of oxygen drops sharply and in 3-4 hours. after injury is reduced to less than 60% of the original values, although respiratory ability burnt tissues for a long time still remains high. This leads to the rapid development of tissue hypoxia.
Developing an oxygen deficiency leads to the violation of all types of metabolism and affects the function of various organs and systems and, first of all, on the regulatory functions of the Central nervous system.
Y. M. Gefter, G. F. Miloscevic, L. Smirnova, believe that oppression oxidizing processes in burns significantly associated with developing acidosis and hypoproteinemia.
In turn, the reduction of oxidative processes lead to accumulation of products interstitial exchange and further acidosis.
According to Century, Borisov, E. Ya. Gaiman, S., Frieda, A. P. Devonskogo and others, the reduction of oxidative processes in case of burns due to a primary decrease in the activity of oxidative enzyme systems in the tissues.
Experimentally found that the inhibition of the activity of such respiratory enzymes, such as coal carbonic anhydrase, catalase, cytochrome C oxidase, glutathione, flavins enzymes and dehydrate various organs.
The inhibition of enzymatic oxidation processes in tissues leads to the accumulation of a huge number of non-completely oxidized products of metabolism and reduce heat production, which along with the harsh heat leads to changes of the total energy balance.
Thus, in the body of the animal in the various phases of the flow of burn disease is different degrees of violation of the regulatory functions of the Central nervous system, as well as significant biophysical and chemical and humoral changes that lead to the violation of protein, carbohydrate, mineral and gas exchanges.