Enzymes class oxidoreductase

Catalyzed reaction Localization in tissues Physiological role and diagnostic value

Lactate dehydrogenase

The formation of lactic acid from pyruvic (reversible) In cardiac, smooth and skeletal muscle; in blood Activity increases in myocardial infarction, viral hepatitis, leukemia, acute pancreatitis, malignant tumors

Succinate dehydrogenase

The transformation of amber acid fumaric with the formation of H2O In the mitochondria of cells of all tissues One of the enzymes of the tricarboxylic acid cycle; occupies an important place in the processes of metabolism, and in particular the synthesis of amino acids

Glutamatdekarboksilazy

Oxidation and subsequent deamination glutamic acid with the formation of ketoglutarova acid and ammonia In the liver, kidney, heart muscle, brain and other tissues. Not in erythrocytes Activity in the blood poisoning with carbon tetrachloride (CCL4), in cancer, leukemia. Hepatitis and liver cirrhosis appears in erythrocytes

Catalase

Splits the hydrogen to oxygen and water Mostly in the red blood cells and in cells of the liver and kidneys. Missing in plasma Activity in the blood increases in macrocytic anemia, with the introduction of caffeine, theobromine and the accumulation of acetone phone Activity decreases with typhoid fever, scarlet fever, malaria, tuberculosis and malignant tumors. The criterion of enzyme activity in blood catalase number that is determined by the method Bach-Zubkova: one of two samples of blood boil and after incubation both samples with H2O2 titrated solution KMnO4, in the presence of H2SO4. The difference of the two titrations gives catalase number, which is normally 11-20

Cytochromes ("a", "A3", "b", "b5", "c", "c1" and others)

Activation of tissue oxygen (by transfer of electrons and hydrogen flavoproteins on oxygen) In the cells of all tissues Diagnostic value have no. Physiological importance of enzymes of this group is that they are part of the respiratory chain transform energy of oxidation in the energy high energy relations - the energy of ATP