Ozena

Ozena (synonym stinking cold) - pronounced atrophy of the mucous membrane of the nose and pharynx with thick secretions, sykousis in stinking cover. Most valid reason ozeny is considered a violation of the functions of the sympathetic innervation in case of damage or irritation of one of the links wing-palatal site, resulting comes atrophy of the nasal mucosa. Patients osanai complain about poor nasal breathing (with a broad nasal passages), dryness in the throat, coughing, weakness or total absence of sense of smell. Sharp stench from the nose causes patients to avoid communication with people. Treatment: auto-hemotherapy, banked blood transfusion in combination with aeronavigacii, proteinuria (once in 5 days); injection extract of aloe 1 ml daily for 30 days; injection streptomycin 0.25 g 2 times a day, only 20-30 injection (for the effects on the nasal flora). Applied intramuscularly injection of penicillin and infusion of throat penicillin with the simultaneous ingestion of vitamin a, diathermy cervical sympathetic nodes. Local treatment: softening and removal of the nasal cavity crusts by laying in both halves of the nose on 1/2-1 hour indifferent ointments (Diagilevo, alkaline), washing out the nose 3% solution of hydrogen peroxide, a solution of potassium permanganate (1 : 5000), spraying the nasal cavity alkaline solutions, lubrication of the mucous membrane of the nose, pharynx and larynx Lugol solution in glycerine. Ozena often begins in childhood and progresses in the period of activation of the sex glands and regresses with the onset of menopause. In severe cases ozeny apply and surgical treatment, consisting in the narrowing of the nasal passages by podsazhivayut under the mucous membrane of the nose cartilage, bone or plastic plates.

Ozena (ozaena; from the Greek. ozo - smelly; synonym: chronic atrophic stinking cold, Hesse atrophic stinking rhinitis, rhinitis chronica atrophica foetid a) is a chronic disease of the nasal cavity, which is characterized by marked atrophy of all mucosa and bone skeleton turbinates, thick sticky discharge, drying up in the crust and publisher of the stench.
Etiology remains still unclear. There is an assumption about the effect of heredity, of the significance of infectious diseases, injuries, occupational hazards. Ozena more common in women, sometimes exacerbated during menstruation, fades in the fading function of sexual glands. For a long time, much attention was given congenital syphilis and tuberculosis. Further research showed that in syphilis and tuberculosis somewhat similar to About. things arise as a consequence of cicatrical changes of the mucous membrane and trophic lesions of the nerves in the nose; this often happens after repeated endonasal surgery.
Before Acting met the workers in some occupations (for example, the spinners, the tobacco producers, shoemakers, furrier).
Currently Acting as an occupational disease in the USSR almost not observed since changed working conditions, have disappeared, many of occupational hazards.
Pathogenesis. In the past assumed that ozena - infectious disease in developing constitutionally defective membrane of the nose. This hypothesis was not confirmed, although the flora of the nose (including fungi) in patients O. differs from that of the healthy. It seems, depends on environmental changes in the nasal cavity in patients O.
Most modern researchers neurotrophic theory of pathogenesis of O. Disease caused by a dysfunction of the trigeminal nerve, wing-palatal site and cervical sympathetic nodes. With neurotrophic theory of pathogenesis in close connection costs and endocrine theory Acting in whose favor says the progression of the disease in the period of activation of the sex glands and devolution her during fading functions.
Pathological anatomy. When Ozen there is atrophy of not only the mucosa, but also bone skeleton shells. In advanced cases the lower shell is completely disappears, and the average much thinner. The mucous membrane is a very fine and dense, covered with a grayish-white sticky crusts, which are sometimes off hardly together with areas of epithelial mucous membranes, causing a small nose bleeding.
Microscopic examination of the mucous membrane is detected metaplasia cylindrical epithelium in multi-layer flat orogovevshi epithelium. Tubular-botryoidal gland, located in thin connective tissue layer, almost completely disappear. Individual surviving cancer stretched secret. In bone skeleton turbinates are also observed expressed atrophic, dystrophic processes. Typical O. changes may also affect the mucosa of the sinuses, pharynx, larynx.
The clinical picture and over. Ozena often begins in childhood or adolescence, is very slow. At the beginning of the disease is often observed apparent improvement, especially during acute rhinitis.
Patients complain of laying the nose and the rich are getting denser detachable, drying up in the crust. After removing crusts while blowing your nose, nasal breathing becomes free, but there is often little bleeding. When Acting as a rule, there is a significant weakening, and sometimes complete loss of smell due to atrophy of the mucous membrane and hairs olfactory nerve.
When rinoskopia (see) is marked thinning the mucous membrane, in which you can see the dirty-gray sticky viscous peel, sometimes to fill the cavity of the nose.
Distribution of atrophy of the mucous membrane of the nasolacrimal duct contributes to the infection of the lacrimal SAC and development of dacryocystitis. Distribution of Acting on Evstafieva pipe can cause chronic catarrhal otitis. During the transition process on the larynx and trachea observed hoarseness and sometimes difficulty breathing.
The treatment is symptomatic. Used polyvalent serum, vaccine, derived from the nasal mucus patients, endocrine preparations, lysates, replanting canned fabrics, serotherapy, hemotherapy, non-specific stimuli connective tissue (for example, solutions of salts of silver, iron, copper). Produced blockade upper cervical sympathetic unit with implantation of amniotic fluid under the mucous membrane of the nose, aeroionotherapy, in combination with the transfusion. For the effects on the endocrine and autonomic function was applied iodine-iontophoresis.
Clinical experience has shown that these methods do not have advantages over the old methods of symptomatic therapy, which cause irritation of the mucous membrane and its treatment. These methods include massage of the mucous membrane of cotton probe, tamponade nose gauze strips (Marla settle peel), inhalation solution of soda, salt.
Recommend to grease the nose logoiski solution, daily wash it solutions salt, soda, borax with a teaspoon, nasal douche or a spray. The patient should be explained that the smell emit only a crust and therefore should be systematically removed.
To ensure ozeny was offered a lot of various operations, narrowing of the nasal cavity, but they gave only temporary (sometimes long) effect.