Panniculitis

Panniculitis is non-specific, often limited inflammation subcutaneous fat.
There are several forms: pannikulit post, postinjection (introduction oils, paraffin, insulin, physiological solution); pannikulit developing around the inflammatory focus, tumors, cysts; pannikulit intoxication that occur after administration of drugs, often bromine, iodine and others; spontaneous panniculitis, or disease Weber - Christian, and its variant - syndrome Rotmanna - Makai. In spontaneous pannikulit, often accompanied by violation of overall health is affected not only the subcutaneous fatty tissue, but sometimes fatty tissues of internal organs.
Clinically panniculitis is manifested nodes of various sizes, localized or at injection sites and injury, or occur spontaneously in any area of skin, usually on the legs and buttocks. Sites reddish-purple color protrude above the skin, is painful to palpation, sometimes dense due to deposits of calcium salts. Suppuration are extremely rare. Nodes can spontaneously resolved, then they formed a retraction and atrophy, and reappear. Forecast for life favorable, but the disease can be long, relapsing.
The treatment is prescribed penicillin 1 000 000 IU a day, at a rate of up to 15 000 000 IU, corticosteroids (by prescription). Locally advanced dressings with clean Ichthyol.

Panniculitis (panniculitis; from lat. panniculus - cloth, fabric), non - specific, often limited inflammation subcutaneous fat described under different names: cellulite, fat granuloma, lipochrome, tissue necrosis, adiponectin.
Panniculitis is divided into the following forms: 1) on a secondary reaction of adipose tissue, growing around inflammatory lesions, tumors, atheromas, dermoid cysts, etc.; 2) P. artificial, or injecting caused by the introduction in the subcutaneous tissue oils (oleogranulomas), paraffin (paravyoma), insulin (insulin-lipoma), physiological solution; 3) P. traumatic; 4) P. intoxication, caused by ingestion of chemicals, in particular of medicines (iodine, bromine, sulfa drugs, corticosteroids); 5) P. infectious (viral, subnational and others); 6) P., developing due to congestion; 7) P. spontaneous, or idiopathic, with unclear etiology (some authors restrict the term P. only this form), uniting feverish knotted not nagnaivajutsja P. (see Weber-Christian disease) and, apparently, clinical variant latest - syndrome Rotmanna-Makai.
Along with the defeat of fatty tissue of the skin of a similar nature processes, and particularly in spontaneous pannikulit, can occur in other organs and tissues containing fat (retroperitoneal and perinephral cellulose, sealing).
Histopathological panniculitis is manifested in the form of alopecia, nonspecific inflammatory reaction, the nature of which is determined in most cases the primary lesion of the cells of fat lobules. Less inflammatory process develops mainly in connective tissue strips of separating fat lobules; vascular changes at this comparatively insignificant. In the coming exogenous or endogenous by physico-chemical changes of fat cells (up to release of fat and products of fission) last turn into a foreign body, causing various reactive processes: cell lymphocytic infiltration, growth of granulation tissue, infiltrates sarcoidoma type and other
Clinically panniculitis is characterized by the development of nodes that are localized in subcutaneous adipose tissue, damaging the skin agents, spontaneous P. - on the trunk and extremities. A long, often paroxysmal.
Treatment - see Weber - Christian disease. Cm. also Lipochrome.