Paragranum

Paragranum - a type of chlamydia. Manifests itself by the enlargement of the lymph nodes that most frequently neck, rarely axillary, inguinal, mediastinum and others In contrast to the classical forms of Hodgkin's disease, characterized by a slower, more benign course, often for decades. Treatment of progranulin - see Chlamydia.

Paragranum (paragranuloma; synonymous with paragranum Hodgkin) - a type of chlamydia, other than slow benign clinical course, histological pattern, and prognosis. Some authors consider that there are no grounds for allocation of programului in independent form, as between programului and classic chlamydia there are gradual transitional forms with outcomes in Hodgkin's disease or directly to the sarcoma, Hodgkin's lymphoma. More correct to consider progranulin not as a special form of the disease, and as benign scenario of disease Hodgkin's disease (see), referring to the possibility of converting it into a classical picture of chlamydia or sarcoma.
The disease begins with increase cervical, axillary or less inguinal lymph nodes, which rarely exceed 3 cm in diameter, painless, mobile, and in this state can remain for decades; in the context of sites of yellowish-grey colour. Fever, weakness, loss of appetite, weight loss, usually absent. Microscopically normal structure of the lymph nodes sometimes generally saved, but more often, it is partially or completely violated;
follicles can be well defined and have only seen a marked increase in cellular activity; in other cases, the follicles and peripheral sinuses indistinguishable from cell infiltration. Prevailing proliferating cell forms are Mature lymphocytes, which may lead to the erroneous diagnosis lymphocytoma or lymphosarcoma (Fig). Diagnosis of progranulin is based on the detection of Sternberg cells (Fig., 1), which occur mainly in the pulp, the amount of which can vary; mitoses in these rare, but morphologically these cells are identical observed with chlamydia. Meet reticular cells, where you can see the decay products; sometimes they form a focal accumulations similar to the pockets when sarcode Beck. Often found in a small number of plasma cells, eosinophils. The process does not apply to capsule lymph node, necrosis and fibrosis, as a rule, are absent. The increase reticular fibers is usually in the medullary layer, not at the follicles. In this way the process can remain as it shows repeat biopsies, during tens years. The internal organs and lymph nodes to other areas of the body, except mediastinal, in the process are not involved.
However, in many cases, the presence of paintings progranulin through different periods of time (from 2-3 to 10-20 years) there has been a shift in Hodgkin's disease, and even sarcoma, Hodgkin's lymphoma.
Treatment - see Chlamydia.

The typical picture of programului: cloth site infiltrated Mature lymphocytes; Sternberg cells (1) with individual mitoses (top - small increase; at the bottom is a large increase).