Pilger anomaly

Pilger anomaly (K. Pelger) - decrease in the number of segments kernel leukocyte. P. A. occurs in approximately one in 1,000 people (I. E. Shcherbatov). In 70 - 100% of neutrophilic leukocytes have a short rod-like (non-segmented) core with a coarse grid chromatin.
Sometimes segmentation nuclei up to two shares in the form of rounded segments of the small sizes, connected by a thin chromatin thread. Segmentation by 3-5 lobes, first described by Unwritten (I.e. Undritz), occurs only rarely. Functional properties of these leukocytes not differ from the normal. Congenital anomaly character of Pilger is proved by its finding in infants, and inheritance - identifying it from one of the parents, and often has several members of one family in different generations. No pathological significance P. A. no, as occurs in otherwise healthy people.
The presence of anomalies of Pelger characterized by a rod-shaped cores of most of neutrophils, may suggest the regenerative shift in leukocyte formula. However, in reality, the neutrophils P. A. different from the usual band neutrophils lag in the development of the kernel from the structural development cell: when P. A. in structural Mature leukocyte form the nucleus remains young. To differentiate P. A. and regenerative shift in leukocyte formula helps the blood samples from family members.