Heart transplantation

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As a first step on this way we have tried to design the most advanced surgical and physiological side methods of transplantation of the heart in the chest dogs. Until our experiments methods of transplantation of the heart in the chest higher animals were not known neither in Russia nor abroad. Isolated attempts of some scientists transplanted heart on the neck and groin area could not give the desired result, as in these cases, the heart is not reported with light, could not accept active participation in circulation, was salivales fabrics and non-Union stopped its activity.
In the process, we are convinced that a heart transplant in the chest, that is where it has to operate, very complex. For many years we have tested more than 20 variants of heart transplant or heart with light from one animal in the chest. All these options were possible to bring the operation to the end and one or another period of time to observe the life of a dog with a transplanted heart. However, they were flawed, and it forced us to continue work on improvement of the method. Currently, we have already significantly closer to your goal.
Heart transplantation was performed as follows. In one series of experiments we were transplanted into the chest of the dog next to her own heart the second, more heart or heart together with one lung removed the other dog.
The next day after the surgery dog with two hearts woke up from the anesthesia; now it was possible to probe the arteries of the extremities very weak and rapid pulse own heart, animal and more rare and complete the pulse of the transplanted heart. The impression was that the circulation of the dog is carried out mainly through the work of the transplanted heart. Then, as he passed post-operative phenomena, the activities of their own hearts were close to normal: in this period the frequency of the beating of their own hearts almost coincided with the rhythm of the transplanted heart.
4 October 1956 the dog, Hound was transplanted into the chest the second heart. In the postoperative period we have introduced into the chest cavity animal with large doses of streptomycin with penicillin, which helped to prevent the development of pleurisy and inflammation around the transplanted heart and provided a good accretion of its vessels with vessels Hound. This dog with two hearts were shown Czechoslovak, American and British surgeons. However, the methods heart transplant this dog was relatively complex and fraught with complications of another nature. During the transplantation was made five major blood vessels, each of which could be clotting of blood assuming the slightest inaccuracy during stitching. It happened in reality. On the 32nd day after the operation appeared fibrillation (disorderly reduction) of the ventricles of the heart, which usually ends his paralysis. Electrocardiogram showed a heart attack * rear wall of the transplanted heart. Therefore, without waiting for the paralysis of the heart, we gave the dog anesthesia, opened the chest and noted normal rhythmic contractions of the Foundation of the transplanted heart (from the confluence of hollow veins) and indiscriminate reduction of muscle fibers of the right ventricle. In the context of left ventricular wall we found a massive stroke, which occurred as a result of blockage supply the heart muscle artery by a blood clot that has formed on the site of vascular suture.
To prevent such complications in the future, we have developed a new scheme transplant additional heart has not five, but only three of vascular seams, and so that if the spot weld is formed, and then off a blood clot, then he will not get in the vessels of the heart, and will be recorded in the vessels of back finitenesses.

* Heart attack - mortification of a part of the heart during blood circulation disorders in it; formed most often as a result of blockage of a feeding artery by a blood clot.