Fluorouracil

Fluorouracil (Phthoruracilum; list a) - antineoplastic. Used in stomach cancer, colon cancer, tumors of the pancreas, lungs, and also for breast cancer and ovarian cancer. Fluorouracil is injected through the day, single dose of 0.75-1 g (15 mg per 1 kg of patient's weight), dose for a course of treatment 3,5-5, Possible side effects: diarrhea, stomatitis, thrombocytopenia, lakopenia, rarely, jaundice. Fluorouracil is contraindicated in cachexia, a sudden breach of the liver and kidneys, radiation (less than 4000 of cells in 1 mm3 the blood) and thrombocytopenia (less than 150 000 platelets in 1 mm3 blood).
The form of release: 5% solution of sodium salt of fluorouracil in sealed to 5 ml Cm. also Antitumor agents.

Fluorouracil (Phthoruracilum; list a) - antineoplastic drug of the group antimetabolites; 5-fluorouracil:
Biochemical data, fluorouracil blocks reactions involved in the formation of a methyl group thymine, and thereby inhibits DNA synthesis tumors and some normal bodies. Part of fluorouracil is included in the RNA, making it a "fake".
Used in cancer of the colon and rectum, stomach cancer, pancreatic, breast, ovary, uterus. In combination with a penetrating radiation can give the effect of lung cancer is increasing sensitivity of cancer Cells to radiation.
To maintain the achieved effect requires repeated courses at intervals in 1-1,5 months.
Fluorouracil is injected intravenously in a day, single dose of 0.75-1 g, a total rate of 3.5 - 5 g, depending on the weight and the condition of the patient. A side effect is expressed in diarrhea and stomatitis, and later in leukopenia, rarely, jaundice. Cm. also Antitumor agents.