Plasma cells

Plasma cells (plasma cells) - a type of cell connection (reticular) tissue, characterized by basophilia cytoplasm. For Mature plasma cells, in addition, typically the peculiar distribution of chromatin in the nucleus, giving the latter type of wheel. On the periphery of the kernel has a bright "halo" a sickle or rings. The amount of plasma cells from 6 to 16 MK, form the most part, rounded, less oval; the kernel is usually eccentric. Basophilia cytoplasm due to high content of RNA that is revealed at colouring by Pronina and research in fluorescent microscope. PAS-reaction inversely proportional to pyroninophilia.
Given cytological feature applies only to a typical Mature plasma cells described in 1895, Marshalko (V. Marschalko). These cells are connected near transitional forms (immature plasma cells, plasmablastic) with their ancestors - reticular cells (and perhaps small and large lymphocytes), cytoplasm which the accumulation of RNA becomes characteristic of the plasma cells basophilia. Electron microscopy revealed some structural parts of cytoplasm arising in the process of maturation of plasma cells and is associated with the formation of antibodies.
Plasma cells are cellular member occurs normally in the mouth, in the mucous membrane of the gastrointestinal tract, nose and respiratory tract, where their presence is probably the immunological response to exposure antigens bacteria, normally inhabit these bodies. They are also found in adventitia large vessels, in gland, stroma functioning excretory gland (breast, salivary); units they are found in the lymph nodes, spleen. Many plasma cells in infiltrates with granulation inflammation of various etiology (syphilis, actinomycosis, gonorrhea, leprosy, rhinoscleroma and so on). Accumulations in their mucous membranes sometimes form a tumor nodes (cancer), and in multiple myeloma bone marrow is affected bone consists almost entirely of atypical plasma cells. The function of plasma cells - see Immunity, immunomorphology.