Polymyxin

Polymyxin (Polymyxinum; list B). To polymyxins is a large group of antibiotics produced by soil bacteria Bacillus polymyxa. Different polymyxins assigned drive letters. The most used - polymyxin M sulfate (Polymyxinum M sulfuricum, Polymyxini M sulfas). Used for treatment of diseases caused by Escherichia coli, dysentery wand wand typhoid and paratyphoid, Escherichia coli, and also in the preparation of patients for operations on the gastrointestinal tract. Assign into tablets 500 000 UNITS 4-6 times a day. The treatment course lasts for 5-10 days. Daily dose inside 2 000-3 000 000 000 IU. External appointed in the form of solution containing 1 ml of 10 000-20 000 IU in 1 ml izotoniceski solution of sodium chloride, or ointments 20 000 IU in 1 g in vaseline. Daily dose of the local application 15 000-20 000 UNITS per 1 kg of body weight. When you receive polimiksina can be observed changes in the kidneys. The use of the drug in patients with renal pathology requires special care. Method of production: the hermetically sealed vials of 500 000 and 1 000 000 UNITS of the drug; tablets of 100 000 and 500 000 IU; ointment in the box for 5, 10, 25 and 50 g, containing 1 g of 20,000 UNITS polymyxin b. Keep in dry place at temperature not above 20 deg. Solutions polimiksina maintained at a temperature of 4 to 10° not more than 7 days. Cm. also Antibiotics.