The tides

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This was sufficient to doctors immediately developed an interest in the combined methods of treatment, including immunotherapy. It is obvious that surgical and radiation therapy methods do not lower the risk of development of malignant cells away from the primary tumor site.
In 60 - 70th years were studied different schemes killed tuberculosis and other bacilli in a variety of malignant tumors, but fundamental changes in the tactics of treatment of oncological patients they had not made. This does not followed that attempts to increase non-specific immunity microbial stimulants (adjuvants) were in vain, however, the success of chemotherapy were more impressive. Remained vague mechanism of action of stimulants and the best time of their introduction.
And yet the value of work mate is difficult to overestimate. It has not become a "hot", but the cold distrust of effects on the immune system in some oncologists was replaced by the interested waiting. This period of the development of theoretical immunology was marked by increased attention to the lymphocytes that are controlled by the thymus (T-lymphocytes). They played the main role in realization of cellular defensive reaction of the immune attack on cancer. Broad recognition of the theory of the immune surveillance of development of malignant tumors in the body (its author - Australian immunologist F. Returns). According to this theory it is T-lymphocytes exercise control over the appearance of atypical cells, including those affected by malignant mutation. Theory corresponded well with the fact that the weakening of the T-immunity observed in congenital immunodeficiencies and drug suppression of reactivity in patients after transplantation them a donor organ, significantly increases the risk of cancer.
But indeed every action causes the same counter, each theory stimulates the emergence of a polar perspective. A number of scientists, among which the most consistently advocated R. run establishment, noted that in some situations, the increase in the number of T-lymphocytes may contribute to tumor formation. Appeared hypothesis immune to cancer." Hard evidence of the absence of immunological surveillance steel observations on specially bred English geneticist C. Flanagan Nude mice, hereditary deprived not only of this body immunity, but hairline (so these mice called "naked", or "Nodame"). In these mice without T-lymphocytes were not rejected alien tissue; hereditary no T-immunity was shortened the life of such mice, but had no effect on the antitumor resistance.
It took some time to immunologists found that among T lymphocytes are cells, indeed, promoting tumor growth (lymphocytes-suppressors), but their activation occurs only in special circumstances. Later it turned out that immunity to tumors is associated not so much with T-lymphocytes, but with independent from the thymus immunological factors.
A more detailed presentation about the immunological protection against cancer has greatly strengthened the position of supporters of the theory of the immune surveillance and eliminated many of the objections of opponents.
Still, the oscillations of the pendulum "hot-cold" continued with high amplitude.