Progesterone

Progesterone (Progesteronum; list B) - hormone yellow body. For therapeutic purposes is obtained by synthesis. Used in functional insufficiency of the yellow body, dysfunctional uterine bleeding, underdevelopment of the genital organs, the usual and threatening miscarriage, infertility (scheme). The highest single and daily doses of progesterone in the muscles 0,025 g (2.5 ml of 1% or 1 ml of 2.5% solution). Progesterone should not be used in pregnancy more than 37 weeks.
The release form: ampoules to 1 ml 1% and 2.5% solution in oil. Keep in protected glare.
Cm. also Sex hormones.

Progesterone is produced mainly in yellow body (temporarily functioning gland of internal secretion, resulting in cycles of the walls of the follicle after ovulation). In addition yellow body, progesterone is in the placenta extract, bark of adrenal glands and testes. The bark of adrenal glands and testes produce progesterone as an intermediate product of the synthesis of corticosteroids and male sex hormone. Progesterone is produced luteal cells yellow body. According to current data, progesterone in small quantities is produced by cells of the granular layer of the follicle before ovulation and education yellow body.
Progesterone is often called the pregnancy hormone, as it selectively acts on the endometrium of the uterus, causing prehravanie changes. Under the influence of progesterone, the endometrium occur expansion, similar to those observed in the early stages of pregnancy. Progesterone sencibilisiruet endometrium and in response to irritation caused by egg is growth decidual tissue of the uterus and of chorion villus leading to the implantation of the egg and the formation of the placenta. Sensitized by progesterone, the endometrium responds to mechanical irritation caused by any outside body. So, flashing lines through tissue of the uterus or the introduction into the cavity glass beads induces the growth of decidual tissue and education decidua or placentae. Progesterone reduces the contraction of the muscle layer of the uterus in response to oxytocin. This is due to the increase in the concentration of sodium and reduction of potassium in the muscle cells of the cervix under the influence of progesterone.
There is a synergy between progesterone and estrogen. Estrogens cause proliferative changes in the uterus, against which there prehravanie expansion under the influence of progesterone. Without prior introduction of estrogen progesterone ineffective. Product exchange progesterone is pregnandiol. He found in the urine and its concentration can be judged on the functional activity of yellow body and the exchange of progesterone. Large doses of progesterone have androgenic (stimulate incremental growth of male sex glands and their secretions). Probably androgenic action of progesterone is the only pharmacological effect, as it is called only large amounts of the hormone.

Progesterone (Progesteronum; synonym: Lutocyclin, Progestin, Proluton) - hormone yellow body cancer obtained by synthesis of 4-pregnen-3,20-dione. Progesterone helps to move mucous membrane of the uterus from the state of proliferation caused estrogenic hormone, secretory state (see Sex hormones). After fertilization, the egg cells progesterone helps to preserve the pregnancy, maintaining the condition of the mucous membrane of the uterus, ensuring the development of the fetus.
Shown with dysfunctional uterine bleeding, amenorrhea, gipooligomenoree, algomenorea, premenstrual mastodynia, infertility associated with the lack of yellow body, familiar and threatened miscarriage. With dysfunctional uterine bleeding is injected intramuscularly in a dose of 5-10 mg daily for 6-8 days; if you made a scraping mucous membrane of the uterine cavity, the introduction of progesterone begins after 12-15 days. When menstrual disorders, premenstrual mastodynia, infertility progesterone applied courses of 5 mg / day or 10 mg a day for 8-10 days prior to menstruation. In amenorrhea courses injection progesterone alternate with the use of estrogen. When the usual and threatening abortion, the use of progesterone may begin early and continue until the complete disappearance of symptoms threatening miscarriage, and with habitual miscarriage - until the fourth month of pregnancy; dose - 5-10 mg daily or every other day.
The release form: ampoules to 1 ml 1% and 2.5% oil solution. Cm. Hormonal drugs.