Protease

Protease (according to the new classification - of peptidoglicana) - enzymes that cleave peptide bonds in proteins and products of their decay. Belong to the class of hydrolases, i.e. enzymes that carry out the gap intramolecular bonds with the accession of elements of water:

Some protease, also catalyze reactions of transpeptidase.
Proteases are one of the largest groups of enzymes; they are found in all animal and plant tissues and organisms. Proteases take part in the processes of protein metabolism, breaking down proteins to amino acids. Protease gastrointestinal tract are allocated in an inactive form as proenzymes or imagenow. Under the influence of different factors (pH environment, the effects of other enzymes, and others) they are then transformed into an active form. A large number of proteases currently selected in the crystalline form.
The nature of proteases are divided into two groups: ekspertizasi (under the old classification is peptidases) and endopeptidase (or PR). Ekspertizasi hydrolyzing dipeptides, and peptide bond polypeptides and proteins formed terminal amino acid residues. Ekspertizasi are divided into dipeptidase, gidrolizuemye dipeptides, amino peptidases, gidrolizuemye peptide bonds formed by the polypeptide chain amino and carboxyl group terminal amino acids, and carboxypeptidase, acting on peptide bonds formed by carboxyl group of polypeptide chain and amino terminal amino acids. Amino peptidases and carboxypeptidase sometimes called polypeptidesee. The carboxypeptidase, produced in the pancreas, is secreted into the intestine in the form of inactive predecessor - procarboxypeptidase, which is activated then trypsin. The carboxypeptidase also found in other organs and tissues of mammals. The most famous ekspertizas is metallovedenie.
Endopeptidazy - enzymes, gidrolizuemye internal peptide bond protein molecule. Specificity of their action depends on the structure of radicals, adjacent to the peptide bond. So, for example, pepsin preferable disconnects, formed by amino group of aromatic amino and carboxyl group aspartic or glutamic acid, and the disease is more easily breaks the peptide bonds in education with the participation of the carboxyl group of tyrosine or phenylalanine.
Protease find wide application in medicine: some of them used to cleanse wounds, eye operations in the fight against thrombosis and so on; trypsin used as anti-inflammatory agents. Cm. also Enzymes.